FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pka-C1Cos-2
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General Information
Symbol
Dmel\Pka-C1Cos-2
Species
D. melanogaster
Name
FlyBase ID
FBal0001784
Feature type
allele
Associated gene
Dmel\Pka-C1
Associated Insertion(s)
Carried in Construct
Also Known As
Cos12, Cos-12
Key Links
Genomic Maps

Allele class

neomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

neomorphic allele - genetic evidence

(Grau and Simpson, 1987)
Mutagen
ethyl methanesulfonate
(Grau and Simpson, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: E130K.

(Collier et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:9,697,179..9,697,179 [-]
Nucleotide change:

G9697179A

Amino acid change:

E130K | Pka-C1-PB; E130K | Pka-C1-PC; E130K | Pka-C1-PD

Reported amino acid change:

E130K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Collier et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Class II allele; lethal when homozygous or in heteroallelic combination with other class II alleles.

      (Lindsley and Zimm, 1992)

      Local pattern duplications of wing and haltere. Mutant embryos show the same intrasegmental deletion-duplication phenotype typical of cos mutants, and 75% show a disturbed denticle polarity that resembles the paternally rescued cos mutants. A number of embryos fail to differentiate anterior parts. These defects begin at the anterior pole and spread posteriorly.

      (Grau and Simpson, 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pka-C1Cos-2 cosV1/cosV5 flies have abnormal legs. fuJ; Pka-C1Cos-2 cosV1/cosV5 flies show a cos phenotype in the thorax and legs.

      (Sanchez-Herrero et al., 1996)

      cosV1 Pka-C1Cos-2/+ individuals display severe outgrowth of the anterior compartment of the wing disc.

      (Capdevila et al., 1994)

      Wings are duplicated when transheterozygous with Df(2R)CA58 (cos-). The phenotype of embryos resulting from crosses involving viable alleles of cos and Pka-C1Cos-2 or Pka-C1Cos-3 indicate a maternal effect on the interaction between Pka-C1 and cos. If the female parent is heterozygous for a viable allele of cos and Pka-C1Cos-2 or Pka-C1Cos-3, and the male parent for Pka-C1Cos-2 or Pka-C1Cos-3, 11% of the embryos show a strong bicaudal phenotype (whereas the reciprocal cross produces less than 1% bicaudal embryos). cosV2, Pka-C1Cos-2/Df(2R)CA58 animals die at various stages of development. The most extreme imaginal phenotypes are observed in those flies that metamorphose but fail to hatch from the pupal case. Pattern duplications can occur on the anterior compartments of all segments of the body, by addition of extra pattern elements, with the possible exception of the clypeolabrum. In the abdomens the smaller anterior bristles are replaced by larger bristles, similar to those that are seen posteriorly, which point anteriorly. The dark pigment is also seen anteriorly. This deletion-duplication phenotype is reminiscent of that seen in cos mutant embryos.

      (Grau and Simpson, 1987)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Penetrance and expressivity are variable. The pattern duplications seen in flies heterozygous for neomorphic "Cos" alleles are indistinguishable from those seen in flies homozygous for leaky alleles of cos.

      (Grau and Simpson, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (7)