FlyBase Allele Report: Dmel\crm[7]

General Information

Symbol

Dmel\crm⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0001834

Feature type

allele

Associated gene

Dmel\crm

Associated Insertion(s)

Carried in Construct

Also Known As

l(1)zw9^k18, zw9^k18

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Judd et al., 1972)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Lethality acts in the late larval or early pupal period. Homozygous female escapers are sterile and have rudimentary ovaries with no oocytes beyond stage 7. Antennae are swollen and the aristae are short with fewer branches than wild type. Male pharate adults have extra sex comb teeth on the second tarsal segment of the prothoracic leg, the first tarsal segment of the mesothoracic leg and occasionally on the first tarsal segment of the metathoracic leg. A rare ectopic sex comb tooth is found on the second tarsal segment of the mesothoracic leg. These are evidence of a proximal to distal transformation.

(Yamamoto et al., 1997)

Hemizygous and homozygous germline clone cells are viable.

(Garcia-Bellido and Robbins, 1983)

Semilethal, survivors exhibit reduced aristae with the third antennal segment blunt and rounded, male prothoracic leg has a second sex comb on the fourth tarsal segment, males have reduced fertility.

(Judd et al., 1972)

Semilethality occurs during larval, pupal and adult stages. Some third instar larvae are inviable, those that survive to puparium formation hatch imagos. Mosaic analysis demonstrates mutant phenotype is non-autonomous. Surviving males have reduced aristae and the third antennal segment is blunt and rounded. Males have an additional sex comb on the second tarsal segment of the prothoracic leg. Males have reduced fertility. Ovaries are rudimentary with no oocytes more advanced that stage 7.

(Shannon et al., 1972)

partially male-fertile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

crm[+]/crm⁷ is an enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

crm[+]/crm⁷ is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Other

Statement

Reference

Pc³, crm⁷ has lethal | pharate adult stage phenotype

(Yamamoto et al., 1997)

Phenotype Manifest In

Enhancer of

Statement

Reference

crm[+]/crm⁷ is an enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

crm[+]/crm⁷ is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Other

Statement

Reference

Pc³, crm⁷ has mesothoracic leg phenotype

(Yamamoto et al., 1997)

Pc³, crm⁷ has metathoracic leg phenotype

(Yamamoto et al., 1997)

PCNA^B1, crm⁷ has sex comb phenotype

(Yamamoto et al., 1997)

PCNA^B1, crm⁷ has prothoracic leg phenotype

(Yamamoto et al., 1997)

Pc³, crm⁷ has sex comb phenotype

(Yamamoto et al., 1997)

PCNA^B1, crm⁷ has mesothoracic leg phenotype

(Yamamoto et al., 1997)

PCNA^B1, crm⁷ has metathoracic leg phenotype

(Yamamoto et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is exacerbated by combination with a single copy of crm⁷.

(Morimoto et al., 2016)

No significant modification of the number of sex combs is seen in crm⁷/+ corto⁴²⁰/+ double heterozygotes compared to crm⁷/+ single heterozygotes.

(Lopez et al., 2001)

Transheterozygotes of Pc³ with crm⁷ die as pharate adults, with second and third legs completely transformed towards the first. Ectopic sex comb teeth are found on the second tarsal segment of all legs. Flies transheterozygous for crm⁷ and mus209^B1 show a strong enhancement of both the proximal to distal and posterior to anterior crm mutant phenotypes. Complete sex combs are present on the first tarsal segments of all legs.

(Yamamoto et al., 1997)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of crm⁷.

(Morimoto et al., 2016)

Complementation and Rescue Data

Rescued by

crm⁷ is rescued by crm^+t14

(Yamamoto et al., 1997)

Not rescued by

crm⁷ is not rescued by crm^rescue-

(Yamamoto et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4281

crm⁷ N^spl-1 sn³/FM7a/Dp(1;2;Y)w⁺

Kyoto

107666

crm⁷, N^spl-1 sn³/FM7a/Dp(1;2;Y)w⁺

Notes on Origin

Discoverer

Comments

Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

(Perrimon et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

63k18

(Thierry-Mieg, 1982)

crm⁷

(Ji et al., 2012, Gibert and Karch, 2011)

k18

(Lim and Snyder, 1974)

l(1)zw9^k18

(Garcia-Bellido and Robbins, 1983, Judd et al., 1972, Shannon et al., 1972)

l(1)zw9^lk18

zw-9^zk18

(Liu and Lim, 1975)

zw9^k18

(Perrimon et al., 1989, Robbins, 1983)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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