FB2026_02 , released June 18, 2026
Allele: Dmel\crn4
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General Information
Symbol
Dmel\crn4
Species
D. melanogaster
Name
FlyBase ID
FBal0001844
Feature type
allele
Associated gene
Dmel\crn
Associated Insertion(s)
Carried in Construct
Also Known As
crnEA130
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Burnette et al., 1999)
Mutagen
ethyl methanesulfonate
(Perrimon et al., 1984)
Progenitor genotype
Cytology

heterochromatic rearrangement

Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show muscle pattern element deletions. Muscles 4, 8, 21, 22 and 23 are most usually affected. Embryos do not demonstrate coordinate movement.

      (Drysdale et al., 1993)

      Hemizygotes display defects in CNS and PNS development. CNS has significantly fewer axons to make up the longitudinal connectives and the intersegmental and segmental nerves in embryos. The PNS has few or no chordotonal organs. Midgut constrictions do not appear, late embryos have a solid yolk plug.

      (Zhang et al., 1991)

      crn4/Df(1)64c18 exhibits a similar phenotype to crn1 but more extreme phenotype, suggesting that it is hypomorphic. Lethal in female germ-line clones.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      crn4 is an enhancer of haltere sensillum phenotype of Ubx9.22

      (Burnette et al., 1999)

      crn4 is an enhancer of haltere sensillum phenotype of Ubx195

      (Burnette et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lefevre.

      Comments
      Comments

      Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

      (Perrimon et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EA130
      (Perrimon et al., 1984)
      crn4
      crnEA130
      (Burnette et al., 1999, Drysdale et al., 1993, Zhang et al., 1991, Perrimon et al., 1989)
      l(1)EA130
      Name Synonyms
      Secondary FlyBase IDs
        References (5)