FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cup20
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General Information
Symbol
Dmel\cup20
Species
D. melanogaster
Name
FlyBase ID
FBal0002165
Feature type
allele
Associated gene
Dmel\cup
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Keyes and Spradling, 1997, Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cup20/cupΔ212 or cup20/Df(2L)BSC7 third instar larvae have significant increases in small extra satellite boutons (for example, budding from parent type 1b boutons) at the (muscle 4) neuromuscular junction (NMJ), compared to wild type or heterozygote controls.

      cup20/cupΔ212 or cup20/Df(2L)BSC7 third instar larvae do not show significant changes in evoked excitatory postsynaptic potential (EPSP) amplitudes (recordings from muscle 6/7 NMJs), but miniature EPSP (mEPSP) frequency (but not amplitude) is significantly increased compared to controls.

      (Menon et al., 2015)

      Egg chambers arrest at stage S5-6. Nurse cell nuclear chromatin appears tightly condensed in the oldest egg chambers.

      (Keyes and Spradling, 1997)

      Abnormalities in follicle cell migration: open ended chorion.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      cup[+]/cup20 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of eIF4E1GD1432

      (Menon et al., 2015)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      cup[+]/cup20 is an enhancer of NMJ bouton | third instar larval stage | increased number phenotype of eIF4E1GD1432

      (Menon et al., 2015)
      Suppressor of
      Statement
      Reference

      cup20 is a suppressor of phenotype of nanos18

      (Verrotti and Wharton, 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      cup20/Df(2L)BSC7 is rescued by Scer\GAL4elav.PU/cupUAS.cMa

      (Menon et al., 2015)
      Not rescued by

      cup20/Df(2L)BSC7 is not rescued by Scer\GAL4how-24B/cupUAS.cMa

      (Menon et al., 2015)
      Comments

      Expression of cupScer\UAS.cMa driven by Scer\GAL4elav.PU significantly rescues the satellite bouton phenotype seen at the NMJ of Df(2L)BSC7/cupΔ212 or Df(2L)BSC7/cup20 third instar larvae; expression driven by Scer\GAL4how-24B fails to rescue the phenotype in Df(2L)BSC7/cup20 larvae.

      (Menon et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cup20
      (Menon et al., 2015)
      cupQL54
      Name Synonyms
      Secondary FlyBase IDs
        References (4)