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General Information
Symbol
Dmel\cv-c1
Species
D. melanogaster
Name
FlyBase ID
FBal0002188
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

cv-c1 heterozygous or homozygous adults exhibit wings with partially missing posterior crossvein compared to controls.

cv-c1 mutant pupal wings lack the presumptive posterior crossvein but the organization of the extracellular matrix appears unperturbed.

Most of the posterior crossvein is missing in homozygous cv-c1 mutants. The remnant of the posterior crossvein is detached, it does not reach the fourth and fifth longitudinal wing veins.

The posterior crossvein appears normal in cv-c1 heterozygotes.

Miniature excitatory junction potentials (mEJPs) recorded at third instar larval neuromuscular junctions of homozygous cv-c1 mutants are not significantly different from that of wild-type larvae.

The amplitudes of excitatory junction potentials (EJPs) evoked by stimulation at 0.3 Hz and recorded at third instar larval neuromuscular junctions of homozygous cv-c1 and heterozygous cv-c1/+ or trans-heterozygous cv-c1/cv-cC524 and cv-c1/cv-cM62 mutants are significantly increased above control levels. As a result, quantal content (QC) is about 70% higher than the QC in the wild-type control.

Expression of cv-cScer\UAS.cDa in motoneurons under the control of Scer\GAL4OK6 fails to rescue the abnormal quantal content (QC) phenotype of cv-c1/+ larvae.

Expression of cv-cScer\UAS.cDa in muscle under the control of Scer\GAL4G14 rescues the abnormal quantal content (QC) phenotype of cv-c1/+ larvae.

There is an increase in the number of T-bars at cv-c1 mutant neuromuscular junctions relative to controls.

In the wings of cv-c1 flies the posterior crossvein is completely absent and the anterior crossvein is detached from the fourth longitudinal vein. cv-c1/cv-cM62 wings display the same posterior crossvein phenotype.

Posterior crossvein usually absent or greatly reduced. Anterior crossvein usually present but often detached. Eye flattened or with vertical shallow furrow. Legs weak, especially tarsal joints. Occasionally overlaps wild type. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

cv-c1 has visible | adult stage phenotype, enhanceable by Dyb11

Suppressed by
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

cv-c1 has wing phenotype, enhanceable by Dyb11

Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Dyb11 heterozygosity or homozygosity enhances the posterior crossvein phenotype of cv-c1 heterozygous adults.

Most of the posterior crossvein is missing in DysE6/+, cv-c1/+ double heterozygotes. The remnant of the posterior crossvein is detached, it does not reach the fourth and fifth longitudinal wing veins.

The increased quantal content (QC) measured at the neuromuscular junction of cv-c1/+ mutants is reduced as a result of expression of DysGS12472 under the control of Scer\GAL4G14.

Heterozygosity for Cdc424 in a cv-c1/+ mutant background restores quantal content (QC) to wild-type levels.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of cv-cScer\UAS.cDa in motoneurons under the control of Scer\GAL4OK6 fails to rescue the abnormal quantal content (QC) phenotype of cv-c1/+ larvae.

Expression of cv-cScer\UAS.cDa in muscle under the control of Scer\GAL4G14 rescues the abnormal quantal content (QC) phenotype of cv-c1/+ larvae.

Images (1)
Stocks (22)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)