cv-c1 heterozygous or homozygous adults exhibit wings with partially missing posterior crossvein compared to controls.
cv-c1 mutant pupal wings lack the presumptive posterior crossvein but the organization of the extracellular matrix appears unperturbed.
Most of the posterior crossvein is missing in homozygous cv-c1 mutants. The remnant of the posterior crossvein is detached, it does not reach the fourth and fifth longitudinal wing veins.
The posterior crossvein appears normal in cv-c1 heterozygotes.
Miniature excitatory junction potentials (mEJPs) recorded at third instar larval neuromuscular junctions of homozygous cv-c1 mutants are not significantly different from that of wild-type larvae.
The amplitudes of excitatory junction potentials (EJPs) evoked by stimulation at 0.3 Hz and recorded at third instar larval neuromuscular junctions of homozygous cv-c1 and heterozygous cv-c1/+ or trans-heterozygous cv-c1/cv-cC524 and cv-c1/cv-cM62 mutants are significantly increased above control levels. As a result, quantal content (QC) is about 70% higher than the QC in the wild-type control.
Expression of cv-cScer\UAS.cDa in motoneurons under the control of Scer\GAL4OK6 fails to rescue the abnormal quantal content (QC) phenotype of cv-c1/+ larvae.
Expression of cv-cScer\UAS.cDa in muscle under the control of Scer\GAL4G14 rescues the abnormal quantal content (QC) phenotype of cv-c1/+ larvae.
There is an increase in the number of T-bars at cv-c1 mutant neuromuscular junctions relative to controls.
In the wings of cv-c1 flies the posterior crossvein is completely absent and the anterior crossvein is detached from the fourth longitudinal vein. cv-c1/cv-cM62 wings display the same posterior crossvein phenotype.
Posterior crossvein usually absent or greatly reduced. Anterior crossvein usually present but often detached. Eye flattened or with vertical shallow furrow. Legs weak, especially tarsal joints. Occasionally overlaps wild type. RK2.