FlyBase Allele Report: Dmel\btl[dev1]

General Information

Symbol

Dmel\btl^dev1

Species

D. melanogaster

Name

FlyBase ID

FBal0002370

Feature type

allele

Associated gene

Dmel\btl

Associated Insertion(s)

Carried in Construct

Also Known As

dev¹

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | larval stage

(Destalminil-Letourneau et al., 2021)

lethal | recessive

(Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Phenotype Manifest In

embryonic/larval crystal cell | increased number | larval stage

(Destalminil-Letourneau et al., 2021)

embryonic/larval tracheal dorsal trunk

(Mariappa et al., 2011)

Detailed Description

Statement

Reference

Generation of the dorsal tracheal trunk is completely abolished in embryos mutant for btl^dev1.

(Mariappa et al., 2011)

btl^dev1/+ third instar larvae have a similar number of boutons per muscle at the neuromuscular junction, compared to controls.

(Sen et al., 2011)

The dominant Pc suppression and recessive lethality of btl^dev1 and btl^dev2 chromosomes result from different lesions as deficiencies that uncover the lethality of btl alleles can exhibit a range of Pc phenotypes: enhancement, suppression or no effect on Pc phenotype.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

btl[+]/btl^dev1 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^how-24B, Smn^{RNAi.C.UAS.WIZ}

(Sen et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

btl[+]/btl^dev1 is an enhancer of NMJ bouton | third instar larval stage phenotype of Scer\GAL4^how-24B, Smn^{RNAi.C.UAS.WIZ}

(Sen et al., 2011)

btl[+]/btl^dev1 is an enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^how-24B, Smn^{RNAi.C.UAS.WIZ}

(Sen et al., 2011)

Suppressor of

Statement

Reference

btl[+]/btl^dev1 is a suppressor of embryonic/larval tracheal section phenotype of Scer\GAL4^btl.PS, Vhl^RNAi.UAS.cMa

(Mortimer and Moberg, 2009)

btl[+]/btl^dev1 is a suppressor of larval tracheal system phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of embryonic/larval tracheal dorsal trunk phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of tracheal lumen phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of embryonic/larval tracheal lateral trunk phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of embryonic/larval dorsal tracheal branch phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of tracheal primordium phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of embryonic/larval ganglionic tracheal branch phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl[+]/btl^dev1 is a suppressor of tracheal fusion cell phenotype of ago³/ago¹

(Mortimer and Moberg, 2007)

btl^dev1 is a suppressor of phenotype of Pc^unspecified

(Lindsley and Zimm, 1992)

btl^dev1 is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

btl^dev1/+ significantly enhances (further reduces) the decreased number of boutons per muscle seen in the neuromuscular junction of third instar Scer\GAL4^how-24B>Smn^{dsRNA.C.Scer\UAS.WIZ} larvae.

(Sen et al., 2011)

btl^dev1/+ leads to a significant reduction in the penetrance of Scer\GAL4^btl.PS Vhl^{dsRNA.Scer\UAS} tracheal phenotypes.

(Mortimer and Moberg, 2009)

A btl^dev1 heterozygous background dominantly suppresses the tracheal phenotypes found in ago¹/ago³ mutants.

(Mortimer and Moberg, 2007)

brm² shows little if any interaction in double heterozygous combination with btl^dev1; less than 3% of flies have held-out wings.

(Vazquez et al., 1999)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter.

(Fauvarque et al., 1995)

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

btl^S084401

(Burmester et al., 2000)

btl^6-81

(Burmester et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4912

btl^dev1/TM1, T(2;3)D⁷, red¹ D⁷

Kyoto

107946

btl^dev1/TM1, T(2;3)D⁷, red¹ D⁷

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

btl^dev1

(Destalminil-Letourneau et al., 2021, Lovato et al., 2019, Mariappa et al., 2011, Sen et al., 2011, Mortimer and Moberg, 2009, Chang et al., 2007, Mortimer and Moberg, 2007)

dev¹

(Vázquez et al., 2008, Boivin et al., 2003, Vazquez et al., 1999, Papoulas et al., 1998, Carpenter, 1997.1.10, Fauvarque et al., 1995, Gindhart and Kaufman, 1995, Kapoun and Kaufman, 1995, Kassis, 1994, Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Name Synonyms

Secondary FlyBase IDs

References (20)

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