FlyBase Allele Report: Dmel\btl[dev2]

General Information

Symbol

Dmel\btl^dev2

Species

D. melanogaster

Name

FlyBase ID

FBal0002371

Feature type

allele

Associated gene

Dmel\btl

Associated Insertion(s)

Carried in Construct

Also Known As

dev²

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

The dominant Pc suppression and recessive lethality of btl^dev1 and btl^dev2 chromosomes result from different lesions as deficiencies that uncover the lethality of btl alleles can exhibit a range of Pc phenotypes: enhancement, suppression or no effect on Pc phenotype.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

btl^dev2 is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

NOT Suppressor of

Statement

Reference

btl^dev2 is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

btl^dev2 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

btl^dev2 is a suppressor of phenotype of Pc^unspecified

(Lindsley and Zimm, 1992)

btl^dev2 is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

btl^dev2 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Other

Statement

Reference

Kr^If-1, btl^dev2/btl[+] has eye phenotype

(Sollars et al., 2003)

Kr^If-1, btl^dev2 has eye phenotype

(Sollars et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

10+/-3% of Kr^If-1/+ flies born to btl^dev2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers.

(Sollars et al., 2003)

brm² shows little if any interaction in double heterozygous combination with btl^dev2; less than 3% of flies have held-out wings.

(Vazquez et al., 1999)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter.

(Fauvarque et al., 1995)

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

btl²

(Sollars et al., 2003)

btl^dev2

(Chang et al., 2007)

dev²

(Vázquez et al., 2008, Kankel et al., 2004, Sollars et al., 2003, Rusch and Kaufman, 2000, Vazquez et al., 1999, Fauvarque et al., 1995, Gindhart and Kaufman, 1995, Kapoun and Kaufman, 1995, Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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