FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dlg15
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General Information
Symbol
Dmel\dlg15
Species
D. melanogaster
Name
FlyBase ID
FBal0002674
Feature type
allele
Associated gene
Dmel\dlg1
Associated Insertion(s)
Carried in Construct
Also Known As
dlglv55, v55
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Thomas et al., 1997)
Mutagen
ethyl methanesulfonate
(Woods and Bryant, 1989, Geer et al., 1983)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In dlg12/dlg15 flies the border follicle cells have much reduced polarity. Delamination of these cells is delayed, but their migration is accelerated.

      (Szafranski and Goode, 2004)

      dlg12/dlg15 animals are viable and have completely normal egg chambers at 18oC. After 6 hours at 25oC, follicle cells exit the follicular epithelium and intermingle with germ cells at the anterior and posterior poles of the egg chamber. Cells that remain in the epithelium retain their polarised characteristics, whereas those that have exited the epithelium have an apolar morphology. Nurse cells extend processes to meet the invasive follicle cells, and the oocyte elongates to contact the cells. Follicle cells at the anterior and posterior ends of the egg chambers preferentially incorporate BrdU. Follicle cells do not have an invasive phenotype in females with homozygous dlg15 clones in the germ cells and follicle cells.

      (Goode and Perrimon, 1997)

      The lethal period is during the late pupal phase.

      (Woods and Bryant, 1989)

      late pupal lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      dlg15 has phenotype, suppressible by Scer\GAL4da.G32/Rnor\Dlg1UAS.cTa

      (Thomas et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Hemizygous males are partially rescued by one copy of Rnor\SAP97Scer\UAS.cTa expressed using Scer\GAL4da.G32, resulting in viable adults which are sterile and unable to fly.

      (Thomas et al., 1997)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Geer.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (10)
      Reported As
      Symbol Synonym
      Dlg15
      (Sarov et al., 2016)
      V55
      (Geer et al., 1983)
      dlg-1v55
      (Thomas et al., 1997)
      dlg15
      (Singh et al., 2020)
      dlglv55
      (Szafranski and Goode, 2004, Goode and Perrimon, 1997)
      dlgv55
      (Peng et al., 2000)
      l(1)L11v55
      (Zhimulev et al., 1987)
      l(1)d.lg-1V55
      (Gateff and Mechler, 1989)
      l(1)v55
      (Geer et al., 1983)
      v55
      (Woods and Bryant, 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)