FlyBase Allele Report: Dmel\dlg1[6]

General Information

Symbol

Dmel\dlg1⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0002675

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

Also Known As

dlg^v59, v59

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Woods and Bryant, 1989, Geer et al., 1983)

Progenitor genotype

Cytology

Description

One third of the guanylate kinase domain is deleted.

(Guan et al., 1996)

14bp deletion starting at 2528bp that shifts the reading frame and deletes two thirds of the GUK domain.

(Woods et al., 1996)

Eliminates most of the guanylate kinase domain.

(Lahey et al., 1994)

14bp deletion in guanylate kinase domain: introduces a stop codon after 12 amino acids.

(Woods and Bryant, 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,405,686..11,405,699 [+]

Comment:

14bp deletion in guanylate kinase domain; introduces a stop codon after 12 amino acids.

(Woods and Bryant, 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

bouton

(Lahey et al., 1994)

imaginal disc

(Woods et al., 1996)

postsynaptic membrane

(Budnik et al., 1996, Guan et al., 1996)

Detailed Description

Statement

Reference

Follicle cells do not have an invasive phenotype in females with homozygous dlg1⁶ clones in the germ cells and follicle cells.

(Goode and Perrimon, 1997)

Presynaptic morphology is normal. Structural defects in the subsynaptic reticulum (SSR), it appears to be underdeveloped. Synaptic transmission is altered; increase in excitatory junctional currents (EJC) amplitude (not due to changes in passive properties of the muscle membrane but due to presynaptic defects causing increased neurotransmitter release).

(Budnik et al., 1996)

The subsynaptic reticulum (SSR) expands more slowly than wild-type and never reaches the final length of wild-type SSR in hemizygous flies. There are no abnormalities in the pathways axons follow, the growth cone morphology, or the time at which the growth cones reach their target and differentiate into boutons on muscles 6, 7, 12 and 13 in hemizygotes.

(Guan et al., 1996)

Homozygous larval show overgrowth of the imaginal discs. Salivary gland cells show no obvious morphological or ultrastructural defects.

(Woods et al., 1996)

Lethality occurs during metamorphosis with neoplastic growth in imaginal discs and CNS. The morphology of the synaptic bouton structure is altered and the subsynaptic reticulum (SSR) is substantially less extensive and less complex than in wild type.

(Lahey et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dlg1[+]/dlg1⁶ is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

dlg1[+]/dlg1⁶ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

dlg1¹²

(Woods et al., 1996)

Fails to complement

dlg1⁷

(Goode and Perrimon, 1997)

dlg1⁵

(Goode and Perrimon, 1997)

dlg1¹⁸

(Goode and Perrimon, 1997)

dlg1¹⁴

(Goode and Perrimon, 1997)

dlg1⁷

(Woods et al., 1996)

dlg1¹⁸

(Woods et al., 1996)

dlg1¹⁵

(Woods et al., 1996)

dlg1¹⁴

(Woods et al., 1996)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

94706

y¹ v¹ dlg1⁶ f¹/FM7a, l(1)*^*/Dp(1;Y)v⁺y⁺

Kyoto

106785

In(1)l-v59, y¹ dlg1⁶/Dp(1;Y)y⁺/C(1)DX, y¹ w¹

Notes on Origin

Discoverer

Geer.

Comments

Class III mutation.

(Woods et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

V59

(Geer et al., 1983)

dlg1⁶

dlg^v59

(Khoury and Bilder, 2020, Gorczyca et al., 2007, Mendoza et al., 2003, Goode and Perrimon, 1997, Tejedor et al., 1997, Thomas et al., 1997, Budnik et al., 1996, Guan et al., 1996, Woods et al., 1996, Lahey et al., 1994, Woods and Bryant, 1991)

l(1)L11^v59

(Zhimulev et al., 1987)

l(1)d.lg-1^V59

(Gateff and Mechler, 1989)

l(1)v59

v59

(Woods and Bryant, 1989)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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