FlyBase Allele Report: Dmel\dpp[d14]

General Information

Symbol

Dmel\dpp^d14

Species

D. melanogaster

Name

FlyBase ID

FBal0003011

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp¹⁴

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Kenyon et al., 2003)

Mutagen

X ray

Progenitor genotype

Caused by aberration

Df(2L)dpp^d14

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size (with dpp^d6)

(Künnapuu et al., 2009)

visible

(Diaz-Benjumea et al., 1994)

visible (with dpp^d6)

(Künnapuu et al., 2009)

visible (with dpp^d6), with Scer\GAL4^dpp.blk1, dpp^{MFSI.III.UAS.Tag:HA}

(Künnapuu et al., 2009)

visible (with dpp^d6), with Scer\GAL4^dpp.blk1, dpp^{MFSI.UAS.Tag:HA}

(Künnapuu et al., 2009)

visible (with dpp^d6), with Scer\GAL4^dpp.blk1, dpp^{UAS.cSa.Tag:HA}

(Künnapuu et al., 2009)

Phenotype Manifest In

genital disc (with dpp^d12)

(Keisman and Baker, 2001)

imaginal disc

(Bryant, 1988)

leg

(Diaz-Benjumea et al., 1994)

muscle cell of A1-7 dorsal oblique muscle 1

(Johnson et al., 2007)

wing

(Posakony et al., 1990)

wing (with dpp^d6)

(Künnapuu et al., 2009)

wing vein L3 (with dpp^d6), with Scer\GAL4^dpp.blk1, dpp^{MFSI.III.UAS.Tag:HA}

(Künnapuu et al., 2009)

wing vein L3 (with dpp^d6), with Scer\GAL4^dpp.blk1, dpp^{MFSI.UAS.Tag:HA}

(Künnapuu et al., 2009)

wing vein L3 (with dpp^d6), with Scer\GAL4^dpp.blk1, dpp^{UAS.cSa.Tag:HA}

(Künnapuu et al., 2009)

Detailed Description

Statement

Reference

dpp^d6/dpp^d14 flies are viable and have small wings.

dpp^d6/dpp^d14 wings are rescued by the expression of dpp^{Scer\UAS.cSa.T:Ivir\HA1} under the control of Scer\GAL4^dpp.blk1 except for ectopic vein materials around longitudinal vein L3.

The size and morphology of dpp^d6/dpp^d14 mutant wings are almost completely rescued by the expression of dpp^{MFSI.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^dpp.blk1 except for ectopic vein material around L3.

The size and morphology of dpp^d6/dpp^d14 mutant wings are almost completely rescued by the expression of dpp^{MFSI.III.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^dpp.blk1 except for ectopic vein material around L3.

(Künnapuu et al., 2009)

The size of some DO1 muscles, particularly in the sixth row of somatic muscles, is reduced in mutant embryos and the space between the DO1 and DO2 muscles is expanded compared to wild type.

(Johnson et al., 2007)

The genital disc is severely reduced in dpp^d12/dpp^d14 larvae.

(Keisman and Baker, 2001)

Heterozygotes of dpp^d12 and dpp^d14 have the distal leg structures missing.

(Diaz-Benjumea et al., 1994)

medulla neuropil ommatidia In dpp^d12/dpp^d14 flies the medulla neuropil is reduced to a size similar to that produced by inactivating wg prior to 44hr AEL. The number of ommatidia is correspondingly reduced.

(Kaphingst and Kunes, 1994)

dpp^d6/dpp^d14 clones are associated with defects in the wing, but not the notum. dpp^d6/dpp^d14 clones in the posterior compartment are associated with normal venation.

(Posakony et al., 1990)

In dpp^d12/dpp^d14 heterozygotes all imaginal discs are extremely reduced, die as early pupae. Imaginal disc transplantation demonstrates that only the anterior notum and most of the proximal anterior wing margin are produced. Wing discs do not have regenerative capacities.

(Bryant, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dpp^d14/dpp[+] is an enhancer of visible | recessive phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

Suppressor of

Statement

Reference

dpp^d14 is a suppressor | partially of increased size | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

dpp^d14/dpp[+] is a suppressor of visible | recessive phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

Phenotype Manifest In

Enhancer of

Statement

Reference

dpp^d14/dpp[+] is an enhancer of eye phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

dpp^d14/dpp[+] is an enhancer of antenna phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

dpp^d14/dpp[+] is an enhancer of genitalia phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

Suppressor of

Statement

Reference

dpp^d14 is a suppressor | partially of wing disc anterior compartment | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

dpp^d14/dpp[+] is a suppressor of wing phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance and expressivity of eye, antenna and genitalia defects seen in dally⁰⁶⁴⁶⁴ homozygotes is increased if they are also heterozygous for dpp^d14. The wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes are suppressed if they are also heterozygous for dpp^d14.

(Jackson et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

dpp^d6/dpp^d14 is partially rescued by Scer\GAL4^dpp.blk1/dpp^{UAS.cSa.Tag:HA}

(Künnapuu et al., 2009)

dpp^d6/dpp^d14 is partially rescued by Scer\GAL4^dpp.blk1/dpp^{MFSI.UAS.Tag:HA}

(Künnapuu et al., 2009)

dpp^d6/dpp^d14 is partially rescued by dpp^{MFSI.III.UAS.Tag:HA}/Scer\GAL4^dpp.blk1

(Künnapuu et al., 2009)

dpp^d14/dpp^d12 is partially rescued by dpp^UAS.E.EGFP/Scer\GAL4^dpp.blk1

(Entchev et al., 2000)

Not rescued by

dpp^d6/dpp^d14 is not rescued by dpp^{MFSII.UAS.Tag:HA}

(Künnapuu et al., 2009)

dpp^d14/dpp^d12 is not rescued by dpp^TnJMB7

(Masucci et al., 1990)

Comments

dpp^d6/dpp^d14 wings are rescued by the expression of dpp^{Scer\UAS.cSa.T:Ivir\HA1} under the control of Scer\GAL4^dpp.blk1 except for ectopic vein materials around longitudinal vein L3.

The expression of dpp^{MFSII.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^dpp.blk1 fails to rescue the wing phenotype of dpp^d6/dpp^d14 mutants.

(Künnapuu et al., 2009)

Allele class: d-V

Images (0)

Mutant

Wild-type

Stocks (3)

3555

107093

101483

Notes on Origin

Discoverer

Spencer.

Comments

dpp class V allele.

(Segal and Gelbart, 1985)

Two copies fail to rescue defects of class V heterozygote dpp^d12/dpp^d14, individuals fail to form cuticle, most do not eclose from the pupal case, those that do have near full size wings and some legs are missing tarsal segments.

(Masucci et al., 1990)

Clonal analysis shows a requirement for dpp⁺ function in cells adjacent to the anterior-posterior compartment boundary of the wing primordium.

(Posakony et al., 1990)

Remove most or all of the imaginal disc function of dpp.

(Lecuit et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dpp¹⁴

(Chen et al., 1999, Segal and Gelbart, 1985, Spencer et al., 1982)

dpp^D14

(Moreno and Morata, 1999)

dpp^V

(Moreno and Morata, 1999)

dpp^d14

(Gore et al., 2021, Velarde et al., 2021, Norman et al., 2016, Won et al., 2015, Chauhan et al., 2013, Paul et al., 2013, Zhou et al., 2012, Wartlick et al., 2011, Künnapuu et al., 2009, Johnson et al., 2007, Yasunaga et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (32)

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