FlyBase Allele Report: Dmel\dpp[H61]

General Information

Symbol

Dmel\dpp^H61

Species

D. melanogaster

Name

FlyBase ID

FBal0003063

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp^Hin61

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Burke and Basler, 1996, Nellen et al., 1996, Jiang and Struhl, 1995, Li et al., 1995, Padgett et al., 1993)

Mutagen

gamma ray

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Small deletion that removes most of the 3' coding exon of dpp (St. Johnston, EMBO J. 6: 2785--2791).

(Padgett et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(St. Johnston et al., 1990)

some die during embryonic stage

(St. Johnston et al., 1990)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryos have a fully ventralised cuticle with a herniated head, ectopic denticle belt replacing the Filzkorper and ventral denticle belts encircling the body.

(Stinchfield et al., 2012)

dpp^H61/dpp^H48 embryos show loss of dorsal tissue and expansion of the lateral denticle bands into dorsal regions. Head involution defects result in extruded globular structures at the anterior of the embryo.

(Das et al., 1998)

Clones in the eye imaginal disc cause a reduction in the size of the eye. Clones in the anterior of the eye completely devoid of dpp (haploinsufficiency is circumvented by using an FRT chromosome containing on the left arm dpp^H61 and on the right arm dpp^Sal20) display normal ommatidia throughout the entire clone.

(Burke and Basler, 1996)

Denticle belts extend around the entire circumference of homozygous embryos.

(Nellen et al., 1996)

Fail to complete germ band extension, die with strong ventralized phenotype and no dorsal derived epidermis.

(St. Johnston et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dpp^H61 is a suppressor of visible | recessive phenotype of Pka-C1^E95

(Phillips et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Df(2L)DTD48/dpp^H61 has embryo phenotype, suppressible by dpp::Hsap\BMP4^fl.cPa

(Padgett et al., 1993)

Suppressor of

Statement

Reference

dpp^H61 is a suppressor of macrochaeta | ectopic | somatic clone | cell non-autonomous phenotype of Pka-C1^E95

(Phillips et al., 1999)

dpp^H61 is a suppressor of wing | somatic clone phenotype of Pka-C1^H2

(Li et al., 1995)

dpp^H61 is a suppressor of scutum | somatic clone phenotype of Pka-C1^H2

(Li et al., 1995)

dpp^H61 is a suppressor of haltere | somatic clone phenotype of Pka-C1^H2

(Li et al., 1995)

dpp^H61 is a suppressor of antenna | somatic clone phenotype of Pka-C1^H2

(Li et al., 1995)

dpp^H61 is a suppressor of leg | somatic clone phenotype of Pka-C1^H2

(Li et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The non-autonomous extra macrochaetae phenotype of Pka-C1^E95 homozygous clones is suppressed if the clones are also homozygous for dpp^H61.

(Phillips et al., 1999)

Clones double mutant for dpp^H61 Pka-C1^E95 do not cause supernumerary structures in the leg and wing. Clones positioned at the compartment boundary exhibit long range effects causing a marked reduction in wing size and loss of vein pattern in anterior and posterior compartments. Short range effects include inducing immediate neighbours to form ectopic veins and margin bristles, the clones fail to differentiate wing veins in a cell autonomous fashion.

(Jiang and Struhl, 1995)

Suppresses the majority of pattern defects caused by Pka-C1^H2 clones in the wing, notum, halteres and antennae and partially suppresses defects in the ventral regions of the leg.

(Li et al., 1995)

Xenogenetic Interactions

Statement

Reference

Three copies of dpp::Hsap\BMP4^fl.cPa fully rescues the embryonic phenotype of dpp^H61/Df(2L)DTD48.

(Padgett et al., 1993)

Complementation and Rescue Data

Rescued by

Df(2L)DTD48/dpp^H61 is rescued by dpp^P23

(Padgett et al., 1993)

Comments

Two copies of dpp^P23 completely rescues the embryonic dorsal-ventral patterning defect of null dpp^H61/Df(2L)DTD48 genotype.

(Padgett et al., 1993)

Mutant phenotype rescued by P element mediated transformation of a wild type copy of dpp.

(Hoffmann and Goodman, 1987)

Allele class: Hin

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

604933

y¹ w^*; dpp^H61/In(2LR)Gla, wg^Gla-1; P{dpp-P23}56

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dpp⁶¹

(Jackson and Hoffmann, 1994)

dpp^H61

dpp^Hin61

(Stinchfield et al., 2012, St. Johnston et al., 1990, Hoffmann and Goodman, 1987)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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