FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\E(z)66
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General Information
Symbol
Dmel\E(z)66
Species
D. melanogaster
Name
FlyBase ID
FBal0003445
Feature type
allele
Associated gene
Dmel\E(z)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

antimorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Jones and Gelbart, 1993, Jones and Gelbart, 1990)

loss of function allele

Mutagen
gamma ray
(Jones and Gelbart, 1990)
Progenitor genotype
E(z)1
(Jones and Gelbart, 1990)
Caused by aberration
Df(3L)E(z)66
Cytology

Polytene chromosomes normal.

(Jones and Gelbart, 1990)
Description

1.5kb deletion uncovering both E(z) and hay.

(Mounkes et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      metaphase & condensed chromosome & embryo

      (O'Dor et al., 2006)
      Detailed Description
      Statement
      Reference

      Early E(z)66 embryos from heterozygous mothers exhibit significantly under-condensed chromatin at metaphase, causing the metaphase plate to increase from the wild-type width of ~2μm to ~5μm. These embryos exhibit chromatid arms that do not properly align at the metaphase plate, but instead project outwards. These embryos show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. This nuclear fallout is not severe and is often observed at the metaphase stage.

      (O'Dor et al., 2006)

      Weak antimorphic suppressor of z1 wis eye colour.

      (Jones and Gelbart, 1990)

      Dominant suppressor of z mutants.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      E(z)66 is a suppressor of phenotype of z1

      (Jones and Gelbart, 1990)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Revertant.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      E(z)1R4
      (Mounkes et al., 1992)
      E(z)66
      (O'Dor et al., 2006)
      E(z)1R4
      E(z)66
      E(z)IR4
      (Jones and Gelbart, 1990)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)