FlyBase Allele Report: Dmel\emc[2]

General Information

Symbol

Dmel\emc²

Species

D. melanogaster

Name

FlyBase ID

FBal0003679

Feature type

allele

Associated gene

Dmel\emc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Ellis et al., 1990)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

macrochaeta | ectopic

(Wrischnik et al., 2003)

posterior scutellar bristle

(Huang et al., 1995)

sensory mother cell

(Huang et al., 1995)

Detailed Description

Statement

Reference

emc²/Df(3L)Ar11 animals have many ectopic macrochaetae, especially on the dorsal notum.

(Wrischnik et al., 2003)

The posterior scutellar bristle is displaced from its normal position in emc²/emc¹¹ flies. Most sensory mother cells emerge earlier in emc¹¹/emc² wing discs compared to wild-type, although the precursor of the posterior scutellar bristle appears later than normal.

(Huang et al., 1995)

The density of chaetae in emc¹/emc² flies with different doses of sc⁺ show a saturation effect on the notum, wing and tergite. The spatial distribution of the chaetae results from cell interactions probably by a mechanism of lateral inhibition.

(del Prado and Garcia-Bellido, 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

emc² has macrochaeta | ectopic phenotype, suppressible by sc^M6/sc[+]

(Wrischnik et al., 2003)

emc² has macrochaeta | ectopic phenotype, suppressible by sc^sisB-2

(Wrischnik et al., 2003)

emc² has macrochaeta | ectopic phenotype, suppressible by sc^sisB-3

(Wrischnik et al., 2003)

emc² has macrochaeta | ectopic phenotype, suppressible by sc^M6

(Wrischnik et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic macrochaetae phenotype in emc²/Df(3L)Ar11 animals is almost completely suppressed by hemizygous sc^M6, but is only weakly suppressed by hemizygous sc^sisB-2 or sc^sisB-3 or by sc^M6/+.

(Wrischnik et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

emc³¹

(Ellis et al., 1990)

emc²⁶

(Ellis et al., 1990)

emc²³

(Ellis et al., 1990)