FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\scM6
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General Information
Symbol
Dmel\scM6
Species
D. melanogaster
Name
FlyBase ID
FBal0046403
Feature type
allele
Associated gene
Dmel\sc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gomez-Skarmeta et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q114term.

(Wrischnik et al., 2003)

Nonsense mutation at position 114.

(Jimenez and Ish-Horowicz, 1997)

Nonsense mutation.

(Parras et al., 1996)

Nucleotide substitution: C1000T.

(Gomez-Skarmeta et al., 1995)

Amino acid replacement: ??term.

(Gomez-Skarmeta et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:396,516..396,516 [+]
Nucleotide change:

C396516T

Reported nucleotide change:

C1000T

Amino acid change:

Q114term | sc-PA

Reported amino acid change:

Q114term

(Wrischnik et al., 2003, Jimenez and Ish-Horowicz, 1997, Gomez-Skarmeta et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      anterior dorsocentral bristle

      (Wrischnik et al., 2003, Gomez-Skarmeta et al., 1995)

      anterior dorsocentral bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      anterior notopleural bristle

      (Wrischnik et al., 2003, Gomez-Skarmeta et al., 1995)

      anterior postalar bristle

      (Marcellini et al., 2005, Gomez-Skarmeta et al., 1995)

      anterior scutellar bristle

      (Gomez-Skarmeta et al., 1995)

      anterior supraalar bristle

      (Gomez-Skarmeta et al., 1995)

      dorsocentral bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      humeral bristle

      (Wrischnik et al., 2003)

      humeral bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      humeral bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      macrochaeta

      (Marcellini et al., 2005)

      microchaeta

      (Marcellini et al., 2005, Gomez-Skarmeta et al., 1995)

      notopleural bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      notopleural bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      ocellar bristle

      (Wrischnik et al., 2003)

      ocellar bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      ocellar bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      orbital bristle

      (Wrischnik et al., 2003)

      orbital bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      orbital bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      postalar bristle

      (Wrischnik et al., 2003)

      postalar bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      postalar bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      posterior postalar bristle

      (Gomez-Skarmeta et al., 1995)

      posterior supraalar bristle

      (Marcellini et al., 2005, Gomez-Skarmeta et al., 1995)

      postocellar bristle

      (Wrischnik et al., 2003)

      postocellar bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      postocellar bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      presutural bristle

      (Wrischnik et al., 2003, Gomez-Skarmeta et al., 1995)

      presutural bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      presutural bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      scutellar bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      scutellar bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      supraalar bristle

      (Wrischnik et al., 2003)

      supraalar bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)

      supraalar bristle (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      vertical bristle 1

      (Wrischnik et al., 2003)

      vertical bristle 2 (with In(1)sc8Lsc4R)

      (Wrischnik et al., 2003)

      vertical bristle (with Df(1)sc19)

      (Wrischnik et al., 2003)
      Detailed Description
      Statement
      Reference

      Females homozygous for scM6 fail to activate the SxlPe (establishment) promoter and subsequently die from dosage compensation upsets.

      (ten Bosch et al., 2006)

      Hemizygous scM6 flies are sterile and lack some sensory bristles. scM6/+ female flies have a very low frequency of missing anterior postalar and posterior supra-alar bristles.

      (Marcellini et al., 2005)

      At 18oC 12% of expected scsisB-2 homozygotes survive to adulthood, but this drops to less than 0.2% when these animals are raised at 25oC. In contrast, hemizygous males are fully viable. With variable penetrance scM6 homozygous adults lack all dorsal head bristles apart from the posterior vertical bristles, and all bristles of the dorsal thorax apart from the posterior notoplural, posterior dorsocentral and scutellar bristles. With variable penetrance scM6/In(1)sc8Lsc4R adults lack all dorsal head bristles apart from the anterior vertical bristles, and all bristles of the dorsal thorax apart from the dorsocentral and bristles. With variable penetrance scM6/Df(1)sc19 adults lack all dorsal head bristles and all dorsal thoracic bristles.

      (Wrischnik et al., 2003)

      The bristle phenotype seen female D.simulans/D.melanogaster hybrids is unaffected by the addition of scM6 at 18oC. At 25oC there is a small general low level increase in bristle loss.

      (Skaer and Simpson, 2000)

      Homozygous embryos develop MP2 neuroblast normally.

      (Parras et al., 1996)

      Females are lethal, most likely because of the absence of sc+ function in the blastoderm. Homozygotes display a reduction in the presence of certain notum bristles. In an ac- background (In(1)y3PLsc8R) the phenotype was improved, only the anterior dorsocentral bristle, posterior supraalar bristle and microchaetae are reduced in numbers.

      (Gomez-Skarmeta et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Df(1)sc19/scM6 has partially lethal - majority die | female phenotype, suppressible by SxlM4/SxlM4

      (Wrischnik et al., 2003)

      scM6 has lethal | recessive | female | heat sensitive phenotype, suppressible by acXSE

      (Wrischnik et al., 2003)

      scM6 has lethal | recessive | female | heat sensitive phenotype, suppressible by Mdoa\scXSE

      (Wrischnik et al., 2003)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      scM6 has anterior postalar bristle phenotype, enhanceable by accami/ac[+]

      (Marcellini et al., 2005)

      scM6 has posterior supraalar bristle phenotype, enhanceable by accami/ac[+]

      (Marcellini et al., 2005)
      Suppressor of
      Statement
      Reference

      scM6/sc[+] is a suppressor of macrochaeta | ectopic phenotype of emc2

      (Wrischnik et al., 2003)

      scM6 is a suppressor of macrochaeta | ectopic phenotype of emc2

      (Wrischnik et al., 2003)

      scM6 is a suppressor of macrochaeta | ectopic phenotype of hhbar3

      (Wrischnik et al., 2003)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      scM6/+, accami/+ double mutants have a significantly increased loss of the anterior postalar, posterior supra-alar and posterior notopleural bristles compared to scM6/+ single mutants.

      (Marcellini et al., 2005)

      The ectopic macrochaetae phenotype in emc2/Df(3L)Ar11 animals is almost completely suppressed by scM6/scM6, but is only weakly suppressed by scM6/+. Ectopic macrochaetae on the scutellum of hhbar3 homozygotes is suppressed by 75% in scM6 hemizygotes.

      (Wrischnik et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      scM6 is rescued by sc+t.XSE

      (ten Bosch et al., 2006)

      scM6 is rescued by sc1xXSE.CAGGcAG

      (ten Bosch et al., 2006)

      scM6 is rescued by sc+t.cass.XSE

      (Wrischnik et al., 2003)

      scM6 is rescued by sc+t.XSE

      (Wrischnik et al., 2003)
      Partially rescued by

      scM6 is partially rescued by sct.3XKO.XSE

      (Wrischnik et al., 2003)

      scM6 is partially rescued by sct.sisB2.XSE

      (Wrischnik et al., 2003)
      Not rescued by

      scM6 is not rescued by sc1xXSE.CAGGTAG

      (ten Bosch et al., 2006)

      scM6 is not rescued by sc3xXSE.CAGGTAG

      (ten Bosch et al., 2006)

      scM6 is not rescued by sct.sisB2.3XKO.XSE

      (Wrischnik et al., 2003)
      Comments

      Expression of sc+t.XSE fully rescues scM6 with respect to female-specific lethality.

      Expression of sc1xXSE.CAGGcAG fully rescues scM6 with respect to female-specific lethality.

      Expression of sc1xXSE.CAGGTAG fails to rescue scM6 with respect to female-specific lethality, with only 35% viability.

      Expression of sc3xXSE.CAGGTAG fails to rescue scM6 with respect to female-specific lethality, with only 3% viability.

      (ten Bosch et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      scM6
      (Phan et al., 2024, Stagg et al., 2011, ten Bosch et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)