FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\en7
Open Close
General Information
Symbol
Dmel\en7
Species
D. melanogaster
Name
FlyBase ID
FBal0003722
Feature type
allele
Associated gene
Dmel\en
Associated Insertion(s)
Carried in Construct
Also Known As
enLA9
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kornberg, 1981)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Kornberg, 1981)
Description

Amino acid replacement: Q52term.

(Gustavson et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,527,517..11,527,517 [-]
Nucleotide change:

C11527517T

Reported nucleotide change:

C?T

Amino acid change:

Q52term | en-PA; Q52term | en-PB

Reported amino acid change:

Q52term

(Gustavson et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Weak allele. Larval/pupal lethal. Some larvae show segmental fusions and occasional escapers show wing phenotypes similar to en1.

      (Gustavson et al., 1996)

      en mutant embryos lack all Keilin's organs. en7/en10 embryos grew in in vivo culture, producing implants containing imaginal discs and all larval tissues. Metamorphosed implants were often characteristic of eye-antenna discs, or sometimes thoracic discs. Tissues derived from the thoracic discs contained only anterior structures.

      (Simcox et al., 1989)

      Male en7/en3 transheterozygotes have abnormal genitalia, with a reduced genital arch process, claspers, hypandrium, hypandrial phragma and penis apparatus.

      (Epper and Sanchez, 1983)

      Homozygous flies die late in embryogenesis. en2/en7 flies survive, although they have reduced viability and severely reduced fertility.

      (Kornberg, 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      en[+]/en7 is a suppressor of increased cell number | oogenesis phenotype of Scer\GAL4C587, Su(var)3-3NIG.17149R

      (Eliazer et al., 2014)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      en7 has phenotype, suppressible | maternal effect by eRF1KY7/eRF1[+]

      (Chao et al., 2003)

      en7 has phenotype, suppressible | maternal effect by eRF1[+]/eRF1F2

      (Chao et al., 2003)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Kornberg.

      Comments
      Comments

      Partially complements other lethal alleles (both point and rearrangement mutations).

      (Gustavson et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      en7
      (Eliazer et al., 2014)
      en9
      (Epper and Sanchez, 1983)
      enLA9
      (Gustavson et al., 1996, Kornberg, 1981)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)