FlyBase Allele Report: Dmel\ewg[1]

General Information

Symbol

Dmel\ewg¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003887

Feature type

allele

Associated gene

Dmel\ewg

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(DeSimone et al., 1996)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | recessive

(Homyk and Emerson, 1988)

lethal - all die during embryonic stage (with ewg²)

(DeSimone et al., 1996)

some die during embryonic stage (with ewg²)

(DeSimone et al., 1996)

viable

(DeSimone et al., 1996, de Simone and White, 1993)

visible | recessive

(Homyk and Emerson, 1988)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell

(Xin et al., 2011, DeSimone et al., 1996)

dorsal longitudinal indirect flight muscle cell (with ewg²)

(DeSimone et al., 1996)

lateral oblique dorsal muscle cell (with ewg²)

(DeSimone et al., 1996)

wing

(Homyk and Emerson, 1988)

Detailed Description

Statement

Reference

Adult ewg¹/ewg² transheterozygotes do not show any significant increase in the number of progenitor cells (intestinal stem cells and enteroblasts) in the midgut, as compared to controls.

(Tian et al., 2017)

The majority of dorsal longitudinal muscles (DLMs) are lost in homozygous ewg¹ mutants.

(Xin et al., 2011)

ewg¹/ewg² pupae exhibit severe IFM defects: a complete loss or severe reduction in the width of the affected muscles.

(DeSimone et al., 1996)

Very reduced viability when heterozygous with a series of yellow terminal deficiencies: neural defects.

(de la Pompa et al., 1989)

Homozygotes are flightless, and 93% have an abnormal wing posture.

(Homyk and Emerson, 1988)

viable Survival of lethal alleles in combination with ewg¹ variable and temperature-sensitive

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ewg¹/ewg² is a suppressor of cell lethal | adult stage phenotype of Apc^Q8

(Xin et al., 2011)

ewg¹/ewg² is a suppressor of abnormal size | adult stage phenotype of Apc^Q8

(Xin et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

ewg¹/ewg² is a suppressor of photoreceptor | adult stage phenotype of Apc^Q8

(Xin et al., 2011)

ewg¹/ewg² is a suppressor of rhabdomere | adult stage phenotype of Apc^Q8

(Xin et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Hemizygous ewg¹/ewg² suppresses the apoptosis seen in Apc^Q8 mutant photoreceptors. The shortening of photoreceptor length seen prior to apoptosis is also suppressed, as is the rhabdomere enlargement seen as a result of misspecification of all of the photoreceptors in the dorsal half of the retina to a dorsal rim area fate.

Homozygous ewg¹ suppresses the apoptosis seen in Apc^Q8 mutant photoreceptors.

(Xin et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

ewg¹/ewg² is partially rescued by ewg^SC3ORF.elav

(DeSimone et al., 1996)

ewg¹ is partially rescued by ewg^hs.PD

(de Simone and White, 1993)

Comments

ewg¹/ewg² lethality can be rescued by ewg^elav.NS. Rescued adults exhibit an erect wing phenotype due to complete absence of DLMs with varying degree of DVM defects. Introduction of ewg^hs.PD to ewg² ewg^elav.NS flies restores DVM and DLM muscles so the adults can fly.

(DeSimone et al., 1996)

Erect wing phenotype is rescued by ewg^hs.PD.

(de Simone and White, 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Hanratty.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ewg

(Homyk and Emerson, 1988)

ewg¹

(Tian et al., 2017, Xin et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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