FlyBase Allele Report: Dmel\exu[VL]

General Information

Symbol

Dmel\exu^VL

Species

D. melanogaster

Name

FlyBase ID

FBal0003919

Feature type

allele

Associated gene

Dmel\exu

Associated Insertion(s)

Carried in Construct

Also Known As

exu^VL57

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

PM hybrid dysgenesis

(Tearle and Nusslein-Volhard, 1987)

P-element activity

(Hazelrigg et al., 1990)

Progenitor genotype

Cytology

Description

Deletion of approximately 700bp, possibly caused by P-element insertion and subsequent imprecise excision.

(Hazelrigg et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

exu transcripts are missing in exu^VL flies.

(Hazelrigg et al., 1990)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Hazelrigg et al., 1990)

lethal - all die during embryonic stage | maternal effect

(Marcey et al., 1991)

male sterile

(Marcey et al., 1991, Hazelrigg et al., 1990)

some die during embryonic stage | maternal effect

(Marcey et al., 1991)

Phenotype Manifest In

embryo, with exu^{333.Tag:StrepII,Venus}

(Lazzaretti et al., 2016)

embryo, with exu^{M68A.Y70A.Tag:StrepII,Venus}

(Lazzaretti et al., 2016)

embryo, with exu^{R92A.Tag:StrepII,Venus}

(Lazzaretti et al., 2016)

embryo (with Df(2R)exu1)

(Lazzaretti et al., 2016)

embryonic head (with exu⁴)

(Irion et al., 2006)

Detailed Description

Statement

Reference

The anterior localization of bcd mRNA is impaired in embryos transheterozygous for exu^VL and any of the following: Df(2R)exu1, exu^{M68A.Y70A.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus}, exu^{R92A.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus} or exu^{333.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus}. The bcd mRNA localization is not impaired when exu^VL is placed in trans to any of these alleles: exu^{FL.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus}, exu^{LDADS.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus}, exu^{D39A.D41A.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus} or exu^{410.T:Zzzz\StrepII,T:Avic\GFP-YFP.Venus}.

osk mRNA localization is not impaired in exu^VL/Df(2R)exu1 embryos.

(Lazzaretti et al., 2016)

exu^VL/exu⁴ embryos lack anterior head structures.

(Irion et al., 2006)

hts RNA localization proceeds normally in embryos derived from exu mutant mothers.

(Ding et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

exu^VL/exu⁴ is a suppressor of visible | homeotic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

exu^VL/exu⁴ is a suppressor of embryonic abdomen | ectopic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

exu^VL/exu⁴ is a suppressor of embryonic thorax phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Other

Statement

Reference

exu^VL/exu⁴, mira^{Δ103.αTub67C.mGFP6} has embryonic head phenotype

(Irion et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Females that express mira^{Δ103.αTub67C.T:Avic\GFP-m6} in an exu^VL/exu⁴ background produce embryos with an exu phenotype, in which the thorax and abdomen develop normally, but the head is absent.

(Irion et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

More than one-third of embryos derived from exu^VL/exu^XL1 ; exu^A6B3 females develop head defects typical of exu mutants.

(Riechmann and Ephrussi, 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Schupbach.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

exu^VL57

(Ding et al., 1993, Marcey et al., 1991, Hazelrigg et al., 1990)

exu^VL

(Lazzaretti et al., 2016, Trovisco et al., 2016, Irion and St Johnston, 2007, Irion and St Johnston, 2007, Irion et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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