FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fs(1)h1
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General Information
Symbol
Dmel\fs(1)h1
Species
D. melanogaster
Name
FlyBase ID
FBal0004278
Feature type
allele
Associated gene
Dmel\fs(1)h
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Digan et al., 1986)
Progenitor genotype
Cytology
Description

Amino acid replacement: G33D.

(Florence and Faller, 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,055,330..8,055,330 [-]
Nucleotide change:

G8055330A

Amino acid change:

G33D | fs(1)h-PA; G33D | fs(1)h-PB; G33D | fs(1)h-PC; G33D | fs(1)h-PD; G33D | fs(1)h-PE; G33D | fs(1)h-PF; G33D | fs(1)h-PG; G33D | fs(1)h-PH; G33D | fs(1)h-PI

Reported amino acid change:

G33D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Florence and Faller, 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      female sterile | heat sensitive

      (Florence and Faller, 2008)

      female sterile | heat sensitive (with Df(1)C128)

      (Florence and Faller, 2008)

      female sterile | heat sensitive (with fs(1)h4)

      (Florence and Faller, 2008)

      female sterile | heat sensitive (with fs(1)hPA)

      (Florence and Faller, 2008)

      female sterile | heat sensitive (with fs(1)hrnc)

      (Florence and Faller, 2008)

      female sterile | maternal effect | recessive | heat sensitive

      (Digan et al., 1986)

      lethal | heat sensitive

      (Kuzin et al., 1994)

      lethal | heat sensitive (with fs(1)h1033B)

      (Florence and Faller, 2008)

      lethal | heat sensitive (with fs(1)hCXE1)

      (Florence and Faller, 2008)

      lethal | maternal effect | heat sensitive

      (Shearn, 1989)

      lethal - all die before end of pupal stage | heat sensitive

      (Digan et al., 1986)

      lethal - all die during embryonic stage | maternal effect | heat sensitive (with fs(1)hPA)

      (Florence and Faller, 2008)

      lethal - all die during embryonic stage | maternal effect | heat sensitive (with fs(1)hrnc)

      (Florence and Faller, 2008)

      lethal - all die during embryonic stage | maternal effect | partially | heat sensitive (with fs(1)h4)

      (Florence and Faller, 2008)

      some die during embryonic stage | maternal effect | heat sensitive (with fs(1)hPA)

      (Florence and Faller, 2008)

      some die during embryonic stage | maternal effect | heat sensitive (with fs(1)hrnc)

      (Florence and Faller, 2008)

      some die during embryonic stage | partially | heat sensitive (with fs(1)h4)

      (Florence and Faller, 2008)

      some die during pupal stage | heat sensitive

      (Digan et al., 1986)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fs(1)h1 female homozygotes are able to lay eggs at 18[o]C, but lose fertility at 26.5[o]C.

      fs(1)hrnc/fs(1)h1 females are fertile at 18[o]C, but are unable to lay eggs at 22[o]C.

      fs(1)hPA/fs(1)h1 females are fertile at 18[o]C, but lose fertility at 25[o]C.

      Df(1)C128/fs(1)h1 females are fertile at 18[o]C, but lose fertility at 25[o]C.

      fs(1)h4/fs(1)h1 females are fertile at 18[o]C, but lose fertility at 26.5[o]C.

      Progeny from fs(1)hPA/fs(1)h1 mothers, raised at semipermissive temperatures (22[o]C), do not hatch. Cuticle analysis reveals very severe head defects, and 95% show segmental fusion of the second abdominal segment. Defects are rarely observed in other segments. The filzkorper is often deleted or malformed.

      Progeny from fs(1)hrnc/fs(1)h1 mothers, raised at semipermissive temperatures (22[o]C), do not hatch. Cuticle analysis reveals that the second abdominal segment is deleted or fused in all of these animals, and most show fusion and mid-line defects in additional segments. The filzkorper is deleted or malformed in 95% of animals. Head structures are often indiscernible and occasionally absent altogether.

      Approximately 50% of progeny from fs(1)h4/fs(1)h1 mothers, raised at semipermissive temperatures (22[o]C), do not survive embryogenesis. Cuticle analysis reveals a weak pair-rule phenotype, which is most consistently observed in even parasegments. 75% of defects seen involve the second abdominal segment.

      (Florence and Faller, 2008)

      Progeny derived from homozygous fs(1)h1 mothers in which oogenesis occurred at an intermediate temperature (23oC) exhibit missing halteres and/or missing third legs or a low frequency of homeotic transformations of the haltere to wing and third to second leg.

      (Shearn, 1989)

      Females hemizygous for fs(1)h1 that also carry Df(3R)red-P93 give rise to progeny with a high frequency of homeotic transformation of T3 to T2. Females heterozygous for fs(1)h1 that also carry Df(3R)red-P93 give rise to progeny with a low but significant frequency of homeotic transformation of T3 to T2.

      (Digan et al., 1986)

      temperature-sensitive

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      fs(1)h1 has phenotype, enhanceable by ash22

      (Shearn, 1989)

      fs(1)h1 has phenotype, enhanceable by trxE5

      (Shearn, 1989)
      Other
      Statement
      Reference

      KrIf-1, fs(1)h1/fs(1)h[+] has eye phenotype

      (Sollars et al., 2003)

      KrIf-1, fs(1)h1 has eye phenotype

      (Sollars et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      10+/-2% of KrIf-1/+ flies born to fs(1)h1/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.

      (Sollars et al., 2003)

      Heterozygosis of ash1 alleles increases the penetrance of homeotic transformations in progeny derived from fs(1)h1 hemizygous mothers: the increase in penetrance is proportional to the loss of ash1 function.

      (Shearn, 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Relative strengths of the mutant alleles estimated as follows: Df(1)C128 = fs(1)h5 = fs(1)h4 > fs(1)h18 > fs(1)h3 > fs(1)h8 > fs(1)h17 > fs(1)h2 > fs(1)h6 > fs(1)h1.

      Relative strengths of the mutant alleles estimated as follows: fs(1)h2 > fs(1)h6 > fs(1)h1 for the temperature sensitive alleles, Df(1)C128 = fs(1)h5 = fs(1)h4 > fs(1)h18 > fs(1)h3 > fs(1)h8 > fs(1)h17 for the non-conditional alleles.

      (Digan et al., 1986)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      fs(1)1456
      (Mohler and Carroll, 1984)
      fs(1)A1456
      fs(1)h1
      (Pherson et al., 2019, Chang et al., 2007)
      fs(1)h1V24
      (Kuzin et al., 1994)
      fs(1)hts1
      (Florence and Faller, 2008)
      fsh1
      (Digan et al., 1986)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)