FlyBase Allele Report: Dmel\g[3]

General Information

Symbol

Dmel\g³

Species

D. melanogaster

Name

FlyBase ID

FBal0004960

Feature type

allele

Associated gene

Dmel\g

Associated Insertion(s)

?{}g³

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lloyd et al., 2002)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

?{}g³

Cytology

Description

4kb insertion in g.

(Lloyd et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color | recessive

(Simpson et al., 1997)

abnormal eye color

(Lloyd et al., 2002, Lloyd et al., 1999)

abnormal eye color (with Df(1)HA92)

(Lloyd et al., 2002)

abnormal eye color | recessive

(Simpson et al., 1997)

visible

(Ooi et al., 1997)

Phenotype Manifest In

Malpighian tubule

(Lloyd et al., 1999)

pigment cell

(Lloyd et al., 1999, Ooi et al., 1997)

pigment granule

(Simpson et al., 1997)

testis sheath

(Lloyd et al., 1999)

Detailed Description

Statement

Reference

Homozygotes have 45% red pigment in the eye compared to 100% in wild-type flies. Df(1)HA92/g³ flies have lower levels of red pigment than g³ homozygotes.

(Lloyd et al., 2002)

In an assay for larval motility, g³ mutants performed as well as wild-type larvae. In locomotor assays testing olfactory response to propionic acid, g³ mutants perform significantly less well than wild-type larvae.

(Mullins et al., 2000)

Eye colour: red pigments are reduced to 45 +/- 1% of wild-type levels, brown pigments are reduced to 70 +/- 8% of wild-type levels in females. Red pigments are reduced to 50 +/- 3% of wild-type levels, brown pigments are reduced to 52 +/- 5% of wild-type levels in males. Malpighian tubule colour: colourless (wild-type colour is orange). Testis colour: yellow (wild-type colour is bright yellow).

(Lloyd et al., 1999)

Eyes exhibit pigmentation defects and reduced number of pigment granules.

(Ooi et al., 1997)

Eye colour: dull brownish. Flies have reduced pigmentation throughout the body; pigment granules are still visible in the ommatidia but contain less pigment than wild-type.

(Simpson et al., 1997)

Like g¹, but gives lighter orange in combination with v. Has 21% normal red pigment and 47% normal brown pigment (Nolte, 1959). Malpighian tubes extremely pale yellow (Brehme and Demerec, 1942). RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Df(1)HA92/g³ has abnormal eye color phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g³ has abnormal eye color phenotype, enhanceable by Df(1)N-8/+

(Lloyd et al., 2002)

g³ has abnormal eye color phenotype, enhanceable by Df(1)N-8/w^e(g)

(Lloyd et al., 2002)

g³ has abnormal eye color phenotype, enhanceable by w^e(g)

(Lloyd et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Df(1)HA92/g³ has pigment cell phenotype, enhanceable by w[+]/w^e(g)

(Lloyd et al., 2002)

g³ has pigment cell phenotype, enhanceable by Df(1)N-8/+

(Lloyd et al., 2002)

g³ has pigment cell phenotype, enhanceable by Df(1)N-8/w^e(g)

(Lloyd et al., 2002)

g³ has pigment cell phenotype, enhanceable by w^e(g)/w^e(g)

(Lloyd et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

g³, w^e(g) double mutant flies have significantly lower levels of red pigment in their eyes than g³ single mutants. Likewise, Df(1)HA92/g³, w^e(g)/+ mutants have lower levels of red pigment in the eye than Df(1)HA92/g³ single mutants. Further, g³, Df(1)N-8/+ double mutant flies have less red pigment in their eyes than the g³, w^e(g) double mutants, while g³, Df(1)N-8/w^e(g) flies have the least pigment of the mutant combinations described here.

(Lloyd et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Bridges, 22nd April 1922.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

g³

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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