FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gpdh1n5-4
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General Information
Symbol
Dmel\Gpdh1n5-4
Species
D. melanogaster
Name
FlyBase ID
FBal0005146
Feature type
allele
Associated gene
Dmel\Gpdh1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Davis and MacIntyre, 1988)

loss of function allele

(O'Brien, 1972)
Mutagen
ethyl methanesulfonate
(Davis and MacIntyre, 1988, O'Brien, 1972)
Progenitor genotype
Gpdh1B
(O'Brien, 1972)
Cytology
Description

Amino acid replacement: C164Y.

(Carmon et al., 2010)

Nucleotide substitution: G?A.

(Carmon et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,946,377..5,946,377 [+]
Nucleotide change:

G5946377A

Reported nucleotide change:

G?A

Amino acid change:

C164Y | Gpdh1-PA; C164Y | Gpdh1-PB; C164Y | Gpdh1-PC; C164Y | Gpdh1-PE; C164Y | Gpdh1-PF; C164Y | Gpdh1-PG

Reported amino acid change:

C164Y

(Carmon et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults are visibly normal but cannot sustain flight.

      (O'Brien, 1972)

      %CRM by rocket electrophoresis: 0 % wildtype enzyme activity: 0 relative enzyme mobility: +GpdhB relative viability: .28 flightless

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      S.J. O'Brien.

      (O'Brien, 1972)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Gpdh1n5-4
      GpdhB0-5-4
      Gpdhn5-4
      n5-4
      (Carmon et al., 2010)
      α-GPDH-1N5-4
      (O'Brien, 1972)
      Name Synonyms
      negative 5-4
      (O'Brien, 1972)
      Secondary FlyBase IDs
        References (6)