FlyBase Allele Report: Dmel\hry[30]

General Information

Symbol

Dmel\hry³⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0005347

Feature type

allele

Associated gene

Dmel\hry

Associated Insertion(s)

Carried in Construct

Also Known As

h^12C, h^12C89

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)

Description

Amino acid replacement: P336L. Nucleotide substitution: C?T.

(Wainwright and Ish-Horowicz, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,678,416..8,678,416 [+]

Nucleotide change:

C8678416T

Reported nucleotide change:

C?T

Amino acid change:

P336L | hry-PA; P336L | hry-PB

Reported amino acid change:

P336L

(Wainwright and Ish-Horowicz, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

lethal | recessive

(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Ingham et al., 1985)

lethal - all die during embryonic stage (with hry²⁶)

(Abed et al., 2011)

pair rule phenotype

(Poortinga et al., 1998)

pair rule phenotype (with hry²⁶)

(Secombe and Parkhurst, 2004, Phippen et al., 2000)

some die during embryonic stage (with hry²⁶)

(Abed et al., 2011)

Phenotype Manifest In

embryonic/first instar larval cuticle (with hry²⁶)

(Secombe and Parkhurst, 2004, Phippen et al., 2000)

embryonic epidermis

(Poortinga et al., 1998)

ventral denticle belt

(Poortinga et al., 1998)

Detailed Description

Statement

Reference

30% of h³⁰/h²⁶ embryos die and do not hatch.

(Abed et al., 2011)

h²⁶/h³⁰ embryos have a pair-rule phenotype, leading to the loss of every second segment.

(Secombe and Parkhurst, 2004)

h²⁶/h³⁰ embryos show a pair-rule cuticle phenotype.

(Phippen et al., 2000)

h²⁶/h³⁰ transheterozygous larvae display a pair-rule phenotype.

(Poortinga et al., 1998)

Weak h phenotypes show enhanced penetrance in embryos derived from mothers with only a single active copy of gro. A4 abdominal denticle belt of heterozygous h embryos from heterozygous gro mothers shows defects.

(Paroush et al., 1994)

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹.

(Ingham et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hry³⁰/hry²⁶ has lethal | embryonic stage phenotype, suppressible | maternal effect | partially by dgrn[+]/dgrn^DK

(Abed et al., 2011)

NOT Enhancer of

Statement

Reference

hry³⁰ is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gug^unspecified

(Zhang et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

hry³⁰/hry²⁶ has embryonic/first instar larval cuticle | pair rule expression pattern phenotype, enhanceable | maternal effect by gro^E47/gro[+]

(Phippen et al., 2000)

Suppressed by

Statement

Reference

hry³⁰/hry²⁶ has embryonic/first instar larval cuticle | pair rule expression pattern phenotype, suppressible | partially by Topors[+]/Topors^AA

(Secombe and Parkhurst, 2004)

gro^E47/gro[+], hry³⁰/hry²⁶ has embryonic/first instar larval cuticle | pair rule expression pattern phenotype, suppressible | maternal effect by CtBP[+]/CtBP⁰³⁴⁶³

(Phippen et al., 2000)

hry³⁰ has phenotype, suppressible by CtBP⁰³⁴⁶³

(Poortinga et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

A maternal copy of dgrn^DK/+ partially suppresses the embryonic lethality of the h³⁰/h²⁶ combination; only 19% of the embryos fail to hatch.

(Abed et al., 2011)

The h²⁶/h³⁰ mutant phenotype is suppressed by Topors^AA/+.

(Secombe and Parkhurst, 2004)

The pair-rule phenotype of h²⁶/h³⁰ embryos is suppressed by one maternal copy of CtBP⁰³⁴⁶³ and is enhanced by one maternal copy of gro^E47. The enhancement of the pair-rule phenotype of h²⁶/h³⁰ embryos caused by one maternal copy of gro^E47 is reversed when one copy of CtBP⁰³⁴⁶³ is also present maternally.

(Phippen et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Nusslein-Volhard.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

h^12C89

(Zhang et al., 2002, Hooper et al., 1989, Ingham et al., 1985)

h^12C

(Bianchi-Frias et al., 2004, Secombe and Parkhurst, 2004, Phippen et al., 2000, Poortinga et al., 1998, Paroush et al., 1994, Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987)

h³⁰

hairy^12C

(Abed et al., 2011)

hry³⁰

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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