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General Information
Symbol
Dmel\hh21
Species
D. melanogaster
Name
FlyBase ID
FBal0005482
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hhIJ35, hhIJ
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Analysis of mRNA and protein shows product is larger than wild-type. Predicted insert not mapped to genomic DNA.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In hh21 mutant embryos, the number of cluster I slou expressing muscle founder cells is reduced to about 3/4 of wild-type. The cluster II slou expressing muscle founder cells ...

No posterior spiracles are present in hh21 larvae.

No significant abnormalities in the corpus cardiacum are detected in late stage mutant embryos.

Mutant animals exhibit separated nerve roots and dendritic fields in the embryonic motor system, as in wild type.

21% of hh21 heterozygotes have increased numbers of S phase larval neuroblasts compared to wild-type.

Mutant embryos have a strong reduction of the head midline epidermis, a reduction in the size of the brain and optic lobe and the total absence of the larval and adult eye primordium.

There are no drastic changes in anal pad development in mutant embryos. The hindgut is shorter than in wild-type embryos (about 70% of the wild-type length at stage 16). The rectum is initially almost normal in size at early stage 12, but begins to degenerate after early stage 13 and is scarcely recognisable at stage 16. The small intestine is also reduced. Growth of the large intestine (which occurs in wild-type embryos after stage 12) is suppressed.

Homozygous embryos lack naked cuticle and develop a lawn of randomly arrayed denticles.

Fat body is slightly reduced.

Homozygous embryos lack naked cuticle between the abdominal denticle belts, these regions are instead covered in denticles.

Posterior naked cuticle is eliminated from every segment.

Larvae exhibit the cardiac arrest phenotype, foregut cells are clustered at the top of the proventriculus and cannot migrate inside to form the cardiac valve. Pupae and adult therefore have no cardiac valve and also the outer wall of the proventriculus is narrow and hollow.

Cuticle phenotype.

Ventral cuticle is covered in denticles.

Embryos are reduced in size and exhibit an absence of naked cuticle in each segment. Double mutant embryos with ptcG12 are larger and exhibit a phenotype similar to ptc.

Strong phenotype. Mutant embryos show no obvious segmentation, and are 40% the length of wild type; denticles form a lawn arranged in a number of whorls on the ventral surface as a result of loss of naked cuticle.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

hh[+]/hh21 is an enhancer of visible phenotype of CycEJP

NOT Enhancer of
Statement
Reference

hh21 is a non-enhancer of visible phenotype of RetMEN2B.GMR

Suppressor of
Statement
Reference

hh21 is a suppressor of visible phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

hh21 is a non-suppressor of abnormal cell migration phenotype of ptcD130

hh21 is a non-suppressor of visible phenotype of RetMEN2B.GMR

Other
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

hh[+]/hh21 is an enhancer of eye phenotype of CycEJP

NOT Enhancer of
Statement
Reference

hh21 is a non-enhancer of eye phenotype of RetMEN2B.GMR

hh21 is a non-enhancer of eye phenotype of Nspl-1

Suppressor of
Statement
Reference

hh21 is a suppressor of eye phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

hh21 is a non-suppressor of eye phenotype of RetMEN2B.GMR

Other
Additional Comments
Genetic Interactions
Statement
Reference

In ptcD130/hh21 double mutant embryos, tracheal ganglionic branch migration is disrupted as it is in ptcD130 single mutants.

trol13/trol13; heterozygous for hh21 have increased numbers of S phase neuroblasts per brain lobe compared to trol13 homozygotes or hh21 heterozygotes.

The hh21 denticle phenotype is not rescued by ciwt.Scer\UAS.T:Ivir\HA1 expressed under the control of Scer\GAL4prd.RG1. The phenotype is partly suppressed by cim1-4.Scer\UAS.T:Ivir\HA1 expressed under the control of Scer\GAL4prd.RG1; embryos develop naked cuticle and the bordering denticles show some segmental organisation.

Has no effect on the eye phenotype of Nspl-1.

P{UAS-ci.A}; P{GawB}h1J3 hh21 embryos exhibit rescue of the posterior naked cuticle.

In hh21;ptc9 double mutants the posterior cuticle within each segment is rescued. Characteristic posterior row of denticles is absent. Denticle belts appear broader and mirror image symmetry is not found.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Strong mutation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (55)