FB2026_03 , released September 17, 2026
Allele: Dmel\kis2
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General Information
Symbol
Dmel\kis2
Species
D. melanogaster
Name
FlyBase ID
FBal0005694
Feature type
allele
Associated gene
Dmel\kis
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

loss of function allele

(Daubresse et al., 1999)
Mutagen
ethyl methanesulfonate
(Kennison and Tamkun, 1988)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the fifth adult abdominal segment show transformation to a more anterior identity, as shown by the loss of the black pigmentation characteristic of this segment. The effect is cell autonomous.

      (Daubresse et al., 1999)

      brm2 shows little if any interaction in double heterozygous combination with kis2; less than 3% of flies have held-out wings.

      (Vazquez et al., 1999)

      No effect on the eye pigment phenotype of wT81.

      (Netter et al., 1998)

      Pairing sensitive repression is unchanged in iab-7 PRE lines that carry kis2.

      (Hagstrom et al., 1997)

      Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter.

      (Fauvarque et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      kis2 is an enhancer of abnormal eye color phenotype of wph-p.lac+3/w1118

      (Bloyer et al., 2003)
      Suppressor of
      Statement
      Reference

      kis2 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Other
      Statement
      Reference

      corto420, kis2 has visible phenotype

      (Lopez et al., 2001)

      corto[+]/corto420, kis2 has visible phenotype

      (Lopez et al., 2001)

      Ras85DV12.sev, kis2, sevS11.Tag:MYC has viable phenotype

      (Maixner et al., 1998)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      kis2 is a suppressor of phenotype of Pc4

      (Kennison and Tamkun, 1988)
      Other
      Statement
      Reference

      corto420, kis2 has posterior crossvein phenotype

      (Lopez et al., 2001)

      corto[+]/corto420, kis2 has posterior crossvein phenotype

      (Lopez et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      kis2 corto420 double heterozygotes show posterior crossvein defects.

      (Lopez et al., 2001)

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by kis2.

      (Maixner et al., 1998)

      Suppresses the extra sex comb phenotype of Pc4, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

      (Kennison and Tamkun, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      kis2
      (Vázquez et al., 2008, Chang et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)