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General Information
Symbol
Dmel\kni2
Species
D. melanogaster
Name
FlyBase ID
FBal0005772
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
kni7G, kni7G75
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T20693984A

Reported nucleotide change:

T2934A

Amino acid change:

C48S | kni-PA; C53S | kni-PB

Reported amino acid change:

C48S

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: T2934A. Amino acid replacement: C48S.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform.

Larval phenotype: abdominal segments A1-A7 fused, dominant defects in A2-A5.

strong

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

kni2 has phenotype, enhanceable by groE48

kni2 has phenotype, enhanceable by gro1

Enhancer of
Statement
Reference

kni2 is an enhancer of phenotype of groE48

kni2 is an enhancer of phenotype of gro1

NOT Enhancer of
Statement
Reference

kni2 is a non-enhancer of embryo | dorsal closure stage phenotype of kay1/kay2

kni2 is a non-enhancer of wing vein | ectopic phenotype of Scer\GAL432B, rlSem.C.UAS

NOT Suppressor of
Statement
Reference

kni2 is a non-suppressor of embryo | dorsal closure stage phenotype of kay1/kay2

kni2 is a non-suppressor of wing vein | ectopic phenotype of Scer\GAL432B, rlSem.C.UAS

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (7)