FB2026_02 , released June 18, 2026
Allele: Dmel\scu174
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General Information
Symbol
Dmel\scu174
Species
D. melanogaster
Name
FlyBase ID
FBal0006237
Feature type
allele
Associated gene
Dmel\scu
Associated Insertion(s)
Carried in Construct
Also Known As
174
Key Links
Genomic Maps

Allele class

loss of function allele

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Torroja et al., 1998)

loss of function allele

(de la Pompa, 1994)
Mutagen
ethyl methanesulfonate
(Torroja et al., 1998, de la Pompa, 1994)
ethyl nitrosourea
(Ferrus et al., 1990)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Ferrus et al., 1990)
Description

Nucleotide substitution: T1137A. Amino acid replacement: L33Q.

(Torroja et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,092,040..18,092,040 [+]
Nucleotide change:

T18092040A

Reported nucleotide change:

T1137A

Amino acid change:

L33Q | scu-PA

Reported amino acid change:

L33Q

(Torroja et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      scu174 shows an early lethal phase during embryogenesis, followed by a major period of lethality around the onset of metamorphosis. Testis size is reduced in males examined before the onset of lethality. Spermatocytes are organised into smaller groups of cells than normal in pupal testes, and sperm bundles are not seen. Numerous necrotic cells are seen and the spermatocytes contain large numbers of fat-containing vesicles. The number of mitochondria in the cytoplasm of the spermatocytes is reduced.

      (Torroja et al., 1998)

      Individuals die as embryos or pupae. Heterozygotes have a Sh phenotype.

      (de la Pompa, 1994)

      Gynandromorph analysis demonstrates the mutation is lethal. Surviving adults have very few and short bristles and small male patches. Homozygous germline clones exhibit lethality of the oogonia. Heterozygotes have a visible shaking activity, CGF action potentials have an abnormal profile.

      (Ferrus et al., 1990)

      Major lethal phase in early pupae. Somatic mosaics in the adult hypoderm show fewer and smaller bristles and smooth ommatidia. Lethal in germ-line mosaics.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      scu174 is rescued by scu+t2.4

      (Torroja et al., 1998)
      Comments

      Male lethality is completely rescued by scu+t2.4.

      (Torroja et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The degree of reduction of testis size varies in the following order: scu174 > scu4058 > scuS152 > scu3127.

      (Torroja et al., 1998)

      Mutation in the haplo-lethal (HL) region of the Sh complex.

      (Ferrus et al., 1990)

      Mutation within the haplo-lethal (HL) region of the Sh complex.

      (de la Pompa, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      174
      (de la Pompa, 1994, Ferrus et al., 1990)
      l(1)16Fd1
      l(1)174
      l(1)17Ad1
      scu174
      Name Synonyms
      Secondary FlyBase IDs
        References (4)