FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lwr02858
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General Information
Symbol
Dmel\lwr02858
Species
D. melanogaster
Name
FlyBase ID
FBal0008009
Feature type
allele
Associated gene
Dmel\lwr
Associated Insertion(s)
P{PZ}lwr02858
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}lwr02858
Cytology
Description

P{PZ} is inserted 560 bp downstream of a putative polyadenylation signal for lwr.

(Epps and Tanda, 1998)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  severe acute respiratory syndrome
      modeled by HCoV-SARS\3aUAS.CUHK-W1.EGFP
      (Wong et al., 2005)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethality acts in the late embryonic to early larval stages. There is an apparent maternal requirement for lwr since embryos lacking only the zygotic gene product display phenotypes that resemble weak to strong alleles of hb, however when both the maternal and zygotic contributions of lwr are removed the embryos show a high penetrance of severe hunchback phenotypes.

      (Epps and Tanda, 1998)

      Embryos transheterozygous for lwr05486 and lwr02858 show cuticle patterns resembling those of lwr118 homozygotes and of lwr05486/lwr118 transheterozygotes: a phenotype intermediate between the bcd and the hb mutant phenotypes. bcd protein is retained in the cytoplasm of lwr05486/lwr02858 transheterozygotes and lwr05486 homozygotes.

      (Epps and Tanda, 1998)

      Lethality acts in the late embryonic or first larval instar stage. Cuticle phenotypes vary from minor, with only a part of T1 missing, to very severe, where embryos lack segments from T1 to A5, and parts of the head. The posterior part of the embryo is always normal. The variation in phenotype is due to variable maternal contribution of lwr function. Removal of maternal contribution increases the proportion of embryos with the severe defects to 60%, but not the severity of the defects.

      (Epps and Tanda, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      lwr02858/Sumok06307 is an enhancer of wing margin phenotype of ct6, mod(mdg4)ul

      (Capelson and Corces, 2006)
      NOT Enhancer of
      Statement
      Reference

      lwr02858 is a non-enhancer of wing vein | ectopic phenotype of CblDv.UAS, Scer\GAL4GMR.PF

      (Robertson et al., 2000)
      Suppressor of
      Statement
      Reference

      lwr02858/Sumok06307 is a suppressor of adult cuticle phenotype of ct6, mod(mdg4)ul

      (Capelson and Corces, 2006)

      lwr02858/Sumok06307 is a suppressor of adult cuticle phenotype of mod(mdg4)ul, y2

      (Capelson and Corces, 2006)

      lwr02858/Sumok06307 is a suppressor of wing margin phenotype of ct6, mod(mdg4)ul

      (Capelson and Corces, 2006)
      NOT Suppressor of
      Statement
      Reference

      lwr02858 is a non-suppressor of wing vein | ectopic phenotype of CblDv.UAS, Scer\GAL4GMR.PF

      (Robertson et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The transheterozygote lwr02858/smt3k06307 suppresses the mod(mdg4)ul suppression of the ct6 jagged wing phenotype, leading to a more jagged and discontinuous wing phenotype. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.

      The transheterozygote lwr02858/smt3k06307 suppresses the mod(mdg4)ul suppression of the y2 cuticle phenotype, leading to a lighter coloration of the abdomen (due to a reduction in y expression). These phenotypic changes occur in approximately 30% of the mutant flies, with the remaining 70% displaying a continuum of less-pronounced effect. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.

      (Capelson and Corces, 2006)

      A lwr02858 mutant background does not affect the extent of ectopic wing veins or eye roughening seen in Scer\GAL4GMR.PF CblDv.Scer\UAS mutants.

      (Robertson et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      lwr4-3

      (Apionishev et al., 2001)

      lwr5

      (Apionishev et al., 2001)

      lwr05486

      (Apionishev et al., 2001)

      lwr01519a

      (BDGP Project Members, 1994-1999)

      lwr05486

      (BDGP Project Members, 1994-1999)
      Partially complements

      lwr05486

      (Epps and Tanda, 1998)

      lwr05486

      (Epps and Tanda, 1998)
      Comments

      Percent hatchability of embryos produced from a cross between lwr05486 and lwr02858 is 75%, whereas hatchability from a cross between ush2 and lwr02858 is 90%.

      (Epps and Tanda, 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Precise excision of the P{PZ} element reverts lethal mutant phenotype to viability.

      (Epps and Tanda, 1998)

      Likely to be a regulatory mutant that may specifically affect transcription during early embryogenesis. Complements ush2. Two excision alleles derived from lwr02858 show greater degree of lethality when transheterozygous with lwr05486 than did lwr02858.

      (Epps and Tanda, 1998)

      Complements: ex01270. Complements: ex02278. Complements: ds05142. Complements: Gsc05341. Complements: α-Adaptin06694. Complements: Sk06101. Complements: l(2)k08915k08915. Complements: l(2)k09610k09610. Complements: Nlek13714.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      l(2)02858
      (Spradling et al., 1999)
      l(2)0285802858
      lwr02858
      (Wong et al., 2005)
      lwr2858
      (Capelson and Corces, 2006)
      lwrsemi2858
      (Apionishev et al., 2001)
      semi02858
      (Robertson et al., 2000)
      semi2858
      (Epps and Tanda, 1998, Epps and Tanda, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)