FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\vri1
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General Information
Symbol
Dmel\vri1
Species
D. melanogaster
Name
FlyBase ID
FBal0008340
Feature type
allele
Associated gene
Dmel\vri
Associated Insertion(s)
Carried in Construct
Also Known As
jf23sz7
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(George and Terracol, 1997)
Mutagen
ethyl methanesulfonate
(George and Terracol, 1997)
Progenitor genotype
Cytology
Description

Mutation introduces a stop codon at position 924 upstream from the bZIP domain.

(Szuplewski et al., 2003)

Amino acid replacement: ??term.

(Szuplewski et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,308,137..5,308,137 [+]
Nucleotide change:

C5308137T

Amino acid change:

Q203term | vri-PA; Q84term | vri-PC; Q203term | vri-PD; Q84term | vri-PE; Q203term | vri-PF

Reported amino acid change:

Q202term

(George and Terracol, 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bristles in homozygous clones are thinner and reduced in size than normal or are missing. The average distance between stout bristles of the triple row is reduced compared to wild type in homozygous clones, which is characteristic of smaller cells. The mean number of ommatidia in the eyes of mosaic flies in which the eyes are homozygous for vri1 is reduced by 17% compared to wild type.

      (Szuplewski et al., 2003)

      The period length of the locomotor activity rhythm is significantly shorter in heterozygotes than in wild-type flies.

      (Blau and Young, 1999)

      Homozygous embryos are shortened and the dorsal epidermis often appears wrinkled and reduced (leading to a slight 'tail-up' phenotype) and trachea are interrupted. Less frequently the head skeleton is abnormal and ventral denticles are fused or missing. Hemizygotes die as larvae. vri1/vri3 transheterozygotes exhibit shortening of wing vein L5.

      (George and Terracol, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      vri[+]/vri1 is an enhancer of wing phenotype of dpphr4/dppd6

      (George and Terracol, 1997)

      vri1 is an enhancer of phenotype of ea161.13

      (George and Terracol, 1997)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mad6/vri1 flies show a wing phenotype: the L5 vein and sometimes the posterior crossvein is shortened and extra vein material is observed along the L2 vein.

      (George and Terracol, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      jf23sz7
      (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
      l(2)25Db1
      l(2)jf23Sz7
      (George and Terracol, 1997)
      l(2)jf23sz7
      sz7
      (Eberl et al., 1997)
      vri1
      (Szuplewski et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)