FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ea161.13
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General Information
Symbol
Dmel\ea161.13
Species
D. melanogaster
Name
FlyBase ID
FBal0031156
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Terracol and Lengyel, 1994)
Mutagen
ethyl methanesulfonate
(Terracol and Lengyel, 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: G371R.

(Jin and Anderson, 1990)

Nucleotide substitution: G1314A.

(Jin and Anderson, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,330,293..15,330,293 [+]
Nucleotide change:

G15330293A

Reported nucleotide change:

G5564A

Amino acid change:

G371R | ea-PA; G240R | ea-PB

Reported amino acid change:

G371R

(Jin and Anderson, 1990)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      62% of embryos derived from ea161.13/+ females crossed to wild-type males die. 100% of the dead embryos are very weakly ventralised (head involution does not occur and some embryos have a tail up phenotype, Filzkorper are normal).

      (Szuplewski and Terracol, 2001)

      62% embryos from heterozygous females crossed to wild type males die and are weakly ventralised. Embryos show failure of head involution and 25% have a 'tail-up' phenotype due to an incomplete retraction of the germ band.

      (George and Terracol, 1997)

      Weakly ventralised embryos. When maternal or zygotic tkv levels are reduced most of the embryos die and show an increased level of ventralisation.

      (Terracol and Lengyel, 1994)

      Embryos weakly ventralized.

      (Jin and Anderson, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      ea161.13 has embryo | embryonic stage 14 phenotype, enhanceable by cype[+]/cype03771

      (Szuplewski and Terracol, 2001)

      ea161.13 has phenotype, enhanceable by put135

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vrik03801

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vrik05901

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vrik09602

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vrik09713

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vrik11805

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by shn1

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri1

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri2

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri5R4.11

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri5R5.24

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri5R5.7

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri5R7.2

      (George and Terracol, 1997)

      ea161.13 has phenotype, enhanceable by vri5R8.4

      (George and Terracol, 1997)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      99% of embryos derived from cype03771/+ ; ea161.13/+ females crossed to wild-type males die with a ventralised phenotype. 10% are very weakly ventralised (head involution does not occur and some embryos have a tail up phenotype, Filzkorper are normal), 80% are weakly ventralised (the head is not involuted, the posterior segments are internalised and the Filzkorper are disorganised) and 10% are moderately ventralised (the ventral denticle belt is extended laterally, Filzkorper are reduced and disorganised, the head is not involuted and the head and thorax are extended and convoluted).

      (Szuplewski and Terracol, 2001)

      When in combination with vrik05901, vrik09713, vri5R5.7, vri5R5.7 and vri5R5.7 all embryos die. When in combination with other vri alleles, Df(2L)tkv2, shn1 and put135 lethality is greatly increased and embryos are more strongly ventralised.

      (George and Terracol, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ea161.13
      (Jin and Anderson, 1990)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)