FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\vrik05901
Open Close
General Information
Symbol
Dmel\vrik05901
Species
D. melanogaster
Name
FlyBase ID
FBal0063677
Feature type
allele
Associated gene
Dmel\vri
Associated Insertion(s)
P{lacW}vrik05901
Carried in Construct
Also Known As
vri5
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(George and Terracol, 1997)
Mutagen
P-element activity
(George and Terracol, 1997)
Progenitor genotype
Associated Insertion(s)
P{lacW}vrik05901
Cytology
Description

P{lacW} insertion in the first intron. The orientation of the P{lacW} element is the same as the direction of vri transcription.

(Szuplewski et al., 2003)

P{lacW} insertion maps to position 757 within the first intron of cDNA e2.

(George and Terracol, 1997)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      15% of stage 11-13 vri2/vrik05901 embryos show tracheal defects. During stages 14-17, 80% of vri2/vrik05901 embryos show weak tracheal defects (the general architecture of the trachea is preserved, but breaking of branches occurs and elongation and branching are abnormal) and 12% show strong tracheal defects (the tracheal architecture is strongly affected with complete disorganization and formation of sacs).

      (Szuplewski et al., 2010)

      vriKG01220/vrik05901 flies have wings which are shorter than normal and which bend downwards, and the posterior scutellar bristles are upturned. Homozygous clones in the wing have pigmented regions that could result from necrosis. Clones at the anterior wing margin have smaller and thinner stout mechanosensory bristles than normal. The space between bristles is reduced, which is characteristic of smaller cells, and the margin is concave. The mean number of ommatidia in the eyes of mosaic flies in which the eyes are homozygous for vrik05901 is reduced by 10% compared to wild type.

      (Szuplewski et al., 2003)

      The period length of the locomotor activity rhythm is significantly shorter in heterozygotes than in wild-type flies.

      (Blau and Young, 1999)

      Homozygous embryo head skeleton is defective. In some embryos the germ band remains extended, suggesting defects in germ band retraction. Some embryos are convoluted, the ventral denticles extend laterally and filzkorper are internal and present an abnormal morphology. Hemizygotes die as larvae. A large number of undeveloped eggs are recovered from germline clones, phenotype can be rescued by paternal contribution of wild type vri.

      (George and Terracol, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      vri[+]/vrik05901 is a suppressor of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      vrik05901 is an enhancer of phenotype of dpphr4

      (George and Terracol, 1997)

      vrik05901 is an enhancer of phenotype of dpphr27

      (George and Terracol, 1997)

      vrik05901 is an enhancer of phenotype of ea161.13

      (George and Terracol, 1997)
      Suppressor of
      Statement
      Reference

      vri[+]/vrik05901 is a suppressor of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements: cype03771. Complements: tkv04415. Complements: l(2)0488404884. Complements: l(2)k01302k01302. Complements: tkvk16713.

      (BDGP Project Members, 1994-1999)

      Mobilisation of the P{lacW} reveals the insertion is responsible for the mutant phenotype. 23 lethal revertant lines are selected and the lines that have a similar phenotype to vri1 and vri2 also die as larvae when hemizygous.

      (George and Terracol, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (12)