FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PolG14
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General Information
Symbol
Dmel\PolG14
Species
D. melanogaster
Name
FlyBase ID
FBal0008417
Feature type
allele
Associated gene
Dmel\PolG1
Associated Insertion(s)
Carried in Construct
Also Known As
tam4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Woodruff and Ashburner, 1979)
Progenitor genotype
Cytology
Description

Single base pair deletion (nucleotide 3201). Mutation is just after conserved DNA polymerase domain Z and results in a frameshift of the rest of the protein.

(Iyengar et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:13,824,376..13,824,376 [-]
Comment:

Mutation is a 1 bp deletion just after conserved DNA polymerase domain Z and results in a frameshift of the rest of the protein.

(Iyengar et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      PolG110

      (Iyengar et al., 1999)
      Fails to complement

      PolG19

      (Iyengar et al., 1999)

      PolG13

      (Iyengar et al., 1999)

      PolG12

      (Iyengar et al., 1999)
      Rescued by

      Df(2L)BSC252/PolG14 is rescued by PolG1GFP

      (Yu et al., 2017)
      Comments

      The lethality of tam4/Df(2L)BSC252 mutants can be rescued by by combination with a single copy of tamGFP.

      (Yu et al., 2017)

      tamRescue complements tam4 to produce viable flies.

      (Bratic et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: a second-site mutation. Probably associated with a second-site mutation, since homozygotes die during early larval stages whereas hemizygotes die during the late third larval instar stage.

      (Iyengar et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      PolG14
      Polγ-α4
      (Meng et al., 2017)
      SF28
      (Woodruff and Ashburner, 1979)
      l(2)34Dc4
      (Ashburner et al., 1999.10.12)
      l(2)br5SF28
      (Woodruff and Ashburner, 1979)
      tam4
      (Bratic et al., 2015)
      tam4
      (Chiang et al., 2019, Yu et al., 2017)
      tamas4
      Name Synonyms
      Secondary FlyBase IDs
        References (7)