Open Close
General Information
Symbol
Dmel\Orc51
Species
D. melanogaster
Name
FlyBase ID
FBal0008428
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A. Mutation is at the 5' splice site of the exon/intron boundary.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Orc51/+ stage 13 egg chambers show a slight reduction in the intensity of BrdU-labelled foci in some follicle cells compared to wild type.

Lethality occurs mostly at the 3rd larval instar stage. BrdU incorporation in third larval instar brains is reduced in homozygotes compared to heterozygotes. Chromosomes are abnormally condensed. Cells are arrested in a metaphase-like state with chromosome congression and spindle defects. There are two types of spindle defects based on severity; in 55% of cases (Class I), most chromosomes appear to congress at the metaphase as a highly condensed chromosome mass, the mitotic spindle is unfocused and spindle fibres are wound about the chromatid mass, and sometimes uneven spindle poles are seen. In 45% of cases (Class II), chromosomes do not congress at the metaphase plate and instead chromatids are seen throughout the spindle and at the spindle poles. In addition, the spindle appears to be diffuse but more focused than Class I. In some cases the spindles are monoastral.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

Orc51/Orc5[+] is a suppressor | partially of follicle cell phenotype of E2f21-188, E2f2329

Additional Comments
Genetic Interactions
Statement
Reference

The ectopic genomic replication that is seen in the follicle cells of stage 13 E2f2329/E2f21-188 egg chambers is partially suppressed by Orc51; the phenotype is suppressed in 36% of egg chambers.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Woodruff.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)