FlyBase Allele Report: Dmel\Hsp110[00082]

General Information

Symbol

Dmel\Hsp110⁰⁰⁰⁸²

Species

D. melanogaster

Name

FlyBase ID

FBal0009366

Feature type

allele

Associated gene

Dmel\Hsp110

Associated Insertion(s)

P{PZ}Hsp110⁰⁰⁰⁸²

Carried in Construct

Also Known As

l(3)00082, Hsc70Cb⁰⁰⁰⁸²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

X ray

(Carpenter, 1994)

Progenitor genotype

Associated Insertion(s)

P{PZ}Hsp110⁰⁰⁰⁸²

Cytology

Description

P{PZ} insertion in the second intron.

(Burmester et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:14,038,277..14,038,277 [-]

(Burmester et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Carpenter, 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Zhang et al., 2010)

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die during embryonic stage | recessive

(Burmester et al., 2000)

some die during embryonic stage | recessive

(Burmester et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsp110⁰⁰⁰⁸²/Hsc70Cb[+] is an enhancer of visible | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Zhang et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hsp110⁰⁰⁰⁸²/Hsc70Cb[+] is an enhancer of eye | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Zhang et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Hsc70Cb⁰⁰⁰⁸²/+ enhances the eye degeneration phenotype caused by expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Zhang et al., 2010)

Complementation and Rescue Data

Fails to complement

Hsp110⁰⁶⁷⁰⁴

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: btl⁰⁰²⁰⁸. Complements: l(3)70Da⁰²⁴⁰². Complements: v(3)03699⁰³⁶⁹⁹. Complements: l(3)05871⁰⁵⁸⁷¹. Complements: l(3)j2E11^j2E11.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hsc70Cb⁰⁰⁰⁸²

(Ribot et al., 2022, Al-Ramahi et al., 2018)

Hsp110⁰⁰⁰⁸²

l(3)00082

(Zhang et al., 2010, Burmester et al., 2000, Spradling et al., 1999)

l(3)00082⁰⁰⁰⁸²

l(3)70Cb⁰⁰⁰⁸²

(Burmester et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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