FlyBase Allele Report: Dmel\eRF1[00103]

General Information

Symbol

Dmel\eRF1⁰⁰¹⁰³

Species

D. melanogaster

Name

FlyBase ID

FBal0009369

Feature type

allele

Associated gene

Dmel\eRF1

Associated Insertion(s)

P{PZ}eRF1⁰⁰¹⁰³

Carried in Construct

Also Known As

l(3)00103

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}eRF1⁰⁰¹⁰³

Cytology

Description

Insertion at -416 relative to the ATG start codon, in the large first exon.

(Chao et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:20,348,705..20,348,705 [+]

(Chao et al., 2003, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with eRF1^KY7)

(Chao et al., 2003)

lethal | recessive

(Spradling et al., 1999)

partially lethal - majority die | recessive

(Berkeley Drosophila Genome Project, 1993.6.1)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

eRF1⁰⁰¹⁰³/eRF1[+] is an enhancer of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

eRF1⁰⁰¹⁰³/eRF1[+] is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

eRF1⁰⁰¹⁰³/eRF1[+] is an enhancer of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Suppressor of

Statement

Reference

eRF1⁰⁰¹⁰³ is a suppressor of phenotype of wg^PE4

(Chao et al., 2003)

NOT Suppressor of

Statement

Reference

eRF1⁰⁰¹⁰³/eRF1[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of eRF1⁰⁰¹⁰³ does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of eRF1⁰⁰¹⁰³ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of eRF1⁰⁰¹⁰³ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Fails to complement

eRF1^KY7

(Chao et al., 2003)

eRF1⁰¹⁸⁵⁰

(BDGP Project Members, 1994-1999)

eRF1^neo28

(BDGP Project Members, 1994-1999)

eRF1¹⁰⁴⁷⁰

(BDGP Project Members, 1994-1999)

eRF1⁰⁵⁶³⁷

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11488

P{PZ}eRF1⁰⁰¹⁰³ ry⁵⁰⁶/MKRS

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: polo⁰¹⁶⁷³. Complements: polo⁰⁶⁰⁸⁹. Complements: DNAprim^j10B2.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BL-11488

(Rollmann et al., 2007)

eRF1⁰⁰¹⁰³

(Ambegaokar and Jackson, 2011)

l(3)00103

(Chao et al., 2003, Spradling et al., 1999)

l(3)00103⁰⁰¹⁰³

l(3)77ABb⁰⁰¹⁰³

(BDGP Project Members, 1994-1999)

l(3)neo28⁰⁰¹⁰³

(Lukinova et al., 1999, Berkeley Drosophila Genome Project, 1993.6.1)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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