FB2025_05 , released December 11, 2025
Allele: Dmel\CrebA03576
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General Information
Symbol
Dmel\CrebA03576
Species
D. melanogaster
Name
FlyBase ID
FBal0009474
Feature type
allele
Associated gene
Dmel\CrebA
Associated Insertion(s)
P{PZ}CrebA03576
Carried in Construct
Also Known As
P{PZ}CrebA03576
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Andrew et al., 1997)
Mutagen
P-element activity
(Rose et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}CrebA03576
Cytology
Description

P{PZ} insertion maps to the first intron.

(Andrew et al., 1997)

Insertion of a P{PZ} element approximately 2.5kb 5' of the second exon, within an intron.

(Rose et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae are 40% the length and the same width as their heterozygous siblings, length differences arise during larva formation as embryos are about the same length as their heterozygous siblings. The larval cuticle of homozygotes is weak, as seen by frequent holes at random positions in the exoskeleton. The dorsal and ventral larval cuticle is composed of pattern elements found in the ventrolateral position in the wild-type larval cuticle.

      (Andrew et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for CrebA03576 has no effect on the evoked excitatory junctional potentials (EJPs) and quantal content (QC) recorded from muscles of homozygous Df(2R)KT40 mutant larvae.

      (Tsurudome et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: l(3)s1754s1754.

      (BDGP Project Members, 1994-1999)

      Precise excision of the P{PZ} element reverts the lethal phenotype demonstrating the insertion is responsible for the lethal phenotype.

      (Andrew et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CrebA03576
      (Mishra et al., 2020, Graves et al., 2015, Iyer et al., 2013, Christensen et al., 2008.4.15)
      l(3)03576
      (Spradling et al., 1999)
      l(3)0357603576
      l(3)3576
      (Rose et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)