FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hmgcr04684
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General Information
Symbol
Dmel\Hmgcr04684
Species
D. melanogaster
Name
FlyBase ID
FBal0009515
Feature type
allele
Associated gene
Dmel\Hmgcr
Associated Insertion(s)
P{PZ}Hmgcr04684
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}Hmgcr04684
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hmgcr04684 homozygotes are lethal when raised at 24[o]C. However, when reared at 19[o]C, 5 and 10% of males and females, respectively, which are developmentally delayed, attempt to survive until adulthood. Quantification of the locomotor activity of these flies indicates that the start/stop number for both sexes is the same.

      Hmgcr04684 heterozygotes exhibit a wild-type phenotype.

      (Belgacem and Martin, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Hmgcr04684 is rescued by Scer\GAL4da.G32/HmgcrUAS.cvDa

      (Belgacem and Martin, 2007)

      Hmgcr04684 is rescued by Scer\GAL4FRT.Act5C/Scer\GAL4Hmgcr.B/HmgcrUAS.cvDa

      (Belgacem and Martin, 2007)
      Partially rescued by

      Hmgcr04684 is partially rescued by Scer\GAL4FRT.Act5C/HmgcrUAS.cvDa

      (Belgacem and Martin, 2007)
      Not rescued by

      Hmgcr04684 is not rescued by Scer\GAL4elav-C155/HmgcrUAS.cvDa

      (Belgacem and Martin, 2007)

      Hmgcr04684 is not rescued by Scer\GAL4to.PD/HmgcrUAS.cvDa

      (Belgacem and Martin, 2007)
      Comments

      Expression of HmgcrScer\UAS.cvDa under the control of Scer\GAL4elav-C155 or Scer\GAL4to.PD fails to rescue the lethality found in Hmgcr04684 homozygotes.

      Expression of HmgcrScer\UAS.cvDa under the control of Scer\GAL4Scer\FRT.Act5C completely rescues lethality, but does not rescue the sexual dimorphism.

      Expression of HmgcrScer\UAS.cvDa under the control of Scer\GAL4da.G32 is sufficient to rescue both the lethality (partly in males - 75%, and completely in females) and the start/stop number (indicating locomotor activity).

      Targeted expression of HmgcrScer\UAS.cvDa under the control of Scer\GAL4Scer\FRT.Act5C and Scer\GAL4Hmgcr.B is sufficient to rescue the sexual dimorphism.

      (Belgacem and Martin, 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: Hmgcr01152. Complements: l(3)0690606906.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hmgcr04684
      hmgcr11635
      (Belgacem and Martin, 2007)
      l(3)04684
      (Spradling et al., 1999)
      l(3)0468404684
      Name Synonyms
      Secondary FlyBase IDs
        References (6)