FB2026_02 , released June 18, 2026
Allele: Dmel\Sar105712
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General Information
Symbol
Dmel\Sar105712
Species
D. melanogaster
Name
FlyBase ID
FBal0009547
Feature type
allele
Associated gene
Dmel\Sar1
Associated Insertion(s)
P{PZ}Sar105712
Carried in Construct
Also Known As
l(3)05712, sar1P1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}Sar105712
Cytology
Description

Insertion in the first intron.

(Yi, 2006)

Insertion of P{PZ} into the 5' exon of sar1.

(Levis, 2002.10.8)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared with wild-type, tracheal tube diameter appears reduced in Sar105712 mutant embryos.

      (Kumichel et al., 2015)

      Transepithelial barrier function in the trachea is normal in mutant embryos.

      (Jayaram et al., 2008)

      Homozygous stage 17 embryos show a "broken hearted" phenotype; the pericardial cells are dissociated from cardioblasts in the dorsal vessel.

      (Yi et al., 2006)

      sar105712 mutants have major defects in cuticular development; the larval cuticles are smaller (on average only 40-50% the length of wild-type) and weaker than the cuticles of their wild-type siblings, the mouthparts and filzkorper are poorly formed, and sar105712 mutants frequently have large holes in the dorsal cuticle. In addition, there appears to be a general defect in patterning of the cuticle, with dorsal and ventral structures appearing more lateralized. The ventral cuticle exhibits a loss of denticles and the denticles that are present have a very light pigmentation, more consistent with the pigmentation found in more lateral denticles of wild-type larvae. The dorsal surfaces of the mutant larvae consist of thin hairs and naked cuticle, an arrangement more typical of dorsal-lateral reiogns of wild-type cuticles.

      (Abrams and Andrew, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Df(3R)ED6085/Sar105712 has lethal phenotype, suppressible by P{FlyFos-045459}

      (Langer et al., 2010)
      Enhancer of
      Statement
      Reference

      Sar1[+]/Sar105712 is an enhancer of visible | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)

      Sar1[+]/Sar105712 is an enhancer of decreased size | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Sar1[+]/Sar105712 is an enhancer of wing phenotype of dpyD

      (Kandasamy et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The lethality of sar105712/Df(3R)ED6085 animals is rescued if they are carrying the P{FlyFos-045685} construct (which contains D. pseudoobscura pseudoobscura fosmid sequence that includes the region orthologous to sar1); a few adults survivors are recovered, and they can fly.

      (Langer et al., 2010)
      Complementation and Rescue Data
      Fails to complement

      Sar107484

      (BDGP Project Members, 1994-1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: epsin-like03685. Complements: howj5B5. Complements: howj5D5. Complements: l(3)rQ178rQ178.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (17)