FB2026_02 , released June 18, 2026
Allele: Dmel\Vha5512
Open Close
General Information
Symbol
Dmel\Vha5512
Species
D. melanogaster
Name
FlyBase ID
FBal0010426
Feature type
allele
Associated gene
Dmel\Vha55
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)SzA12
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)
Mutagen
ethyl methanesulfonate
(Davies et al., 1996, Gausz et al., 1979)
Progenitor genotype
Cytology
Description

Amino acid replacement: S?L.

(Du et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:12,625,171..12,625,171 [-]
Nucleotide change:

C12625171T

Reported nucleotide change:

C?T

Amino acid change:

S377L | Vha55-PA; S377L | Vha55-PB; S377L | Vha55-PC

Reported amino acid change:

S?L

Comment:

Reported as a missense mutation in the third coding exon of Vha55 in the Ser of the string LPSLS from TCG to TTG.

(Du et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants have less opaque Malpighian tubules than controls (when examined by birefringence).

      (Allan et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Vha55[+]/Vha5512 is an enhancer of visible | heat sensitive phenotype of Ivir\M2UAS.cAa, Scer\GAL4GMR.PU

      (Adamson et al., 2011)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Vha55[+]/Vha5512 is an enhancer of eye | heat sensitive phenotype of Ivir\M2UAS.cAa, Scer\GAL4GMR.PU

      (Adamson et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      SzA12
      (Davies et al., 1996)
      Vha5512
      (Vázquez et al., 2008, Chang et al., 2007)
      l(3)SzA12
      (Du et al., 2006, Allan et al., 2005, Gausz et al., 1979)
      vha5512
      (Adamson et al., 2011)
      vha55SzA12
      (Du et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)