FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\B52s2249
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General Information
Symbol
Dmel\B52s2249
Species
D. melanogaster
Name
FlyBase ID
FBal0011148
Feature type
allele
Associated gene
Dmel\B52
Associated Insertion(s)
P{lacW}B52s2249
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{lacW}B52s2249
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      B52s2249 homozygous mutant embryos do not show any hatching delay but show retarded larval growth and die about two days after hatching. The ventral nerve cord of the mutant larvae is narrower than in controls but no obvious structural defects are observed. B52s2249 larvae display defects in muscle movement: the frequency of coordinated muscle contractions is decreased in first instar larvae and second instar larvae appear rigid and paralysed compared to controls.

      The number of ChAT vesicles in larval abdominal neuromeres is significantly decreased relative to controls.

      (Liu and Bossing, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      B52s2249 is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF

      (Mutsuddi et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      B52s2249 is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF

      (Mutsuddi et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      M. Scott.

      Comments
      Comments

      Complements: sqdj4B4. Complements: sqdj6E3. Complements: sqdj8E7.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      B52(s2249P}
      (Liu and Bossing, 2016)
      B52s2249
      (Liu and Bossing, 2016, Fernando et al., 2015, Juge et al., 2010, Ambrus et al., 2009)
      l(3)s2249
      (Spradling et al., 1999)
      l(3)s2249s2249
      (BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)