FlyBase Allele Report: Dmel\lz[s]

General Information

Symbol

Dmel\lz^s

Species

D. melanogaster

Name

spectacled

FlyBase ID

FBal0011830

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Crew et al., 1997, Green and Green, 1956)

Progenitor genotype

Cytology

Description

Deletion of 3957bp in the upstream region and exon I of lz.

(Jackson Behan et al., 2005)

Mutation of cistron B.

(Crew et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:9,281,296..9,285,252 [+]

Comment:

Reported as a deletion of 3,957bp (GB:AF217651 coordinates 4,042–7,998).

(Jackson Behan et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | recessive

(Green and Green, 1956)

increased cell death

(Siddall et al., 2003)

visible

(Siddall et al., 2003, Crew et al., 1997)

visible | recessive

(Batterham et al., 1996, Green and Green, 1956)

Phenotype Manifest In

Detailed Description

Statement

Reference

lz^s adults have a "spectacle" eye phenotype. Ectopic cell death is seen in third larval instar eye discs.

(Siddall et al., 2003)

15% of photoreceptor cell clusters are abnormal, cells R1 and R6 are not recruited properly. Uniform sheet of unorganised cone cells is found. The periphery of the retina contains cells in loosely organised clusters including cone as well as primary and secondary pigment cells, the darker pigment produces the 'spectacle' phenotype. The fenestrated membrane at the base of the retina is shredded.

(Crew et al., 1997)

Homozygotes have a total lack of ommatidial structure in the eye. Pigment is dispersed as a ring around the edge of the eye ("spectacle" phenotype). The entire retina and the underlying lamina are defective. Few, if any, lenses form. The arrangement of the pigment cells is completely deranged, resulting in the complete loss of the fenestrated membrane. Numerous photoreceptor cells are found displacing the lamina. The optic ganglia of the medulla, lobula and lobula plate are also perturbed.

(Batterham et al., 1996)

The antennal funiculus is reduced in size in hemizygous males. All large and small basiconic sensilla on the antennal funiculus are missing, and the number of trichoid sensilla on the antennal funiculus is reduced. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic sensilla on the antennal funiculus is increased and the density of the trichoid sensilla on the antennal funiculus is decreased compared to wild-type.

(Stocker et al., 1993)

Eyes are greatly reduced in size and have a smooth surface in homozygous flies. Red eye pigment is sparse and confined primarily to the margin of the eye. Tarsal claws are vestigial. The spermathecae and pars ovariae are absent in homozygous females.

(Green and Green, 1956)

Eye size reduced, narrower than normal; no true facets; whole eye has glossy surface; color yellow-brown with darker rim, creamy in combination with v. Tarsal claws vestigial. Homozygous females lack spermathecae and parovaria and are sterile. lz^s/+ females tend to have abnormal parovaria (Anderson, 1945). RK1. spectacle; tarsal structures reduced or absent; spermathecae absent; parovaria absent female-sterile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

lz^s has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Suppressor of

Statement

Reference

lz^s is a suppressor of hemocyte phenotype of PPO1^Bc

(Rizki and Rizki, 1981)

lz^s is a suppressor of hemolymph phenotype of PPO1^Bc

(Rizki and Rizki, 1981)

lz^s is a suppressor of embryonic/larval lymph gland phenotype of PPO1^Bc

(Rizki and Rizki, 1981)

Additional Comments

Genetic Interactions

Statement

Reference

Causes suppression of paracrystalline inclusions in hemocytes of Bc¹ larvae. Also suppresses heat-induced blackening of crystal cells in the Bc¹ hemolymph and lymph glands.

(Rizki and Rizki, 1981)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

lz^50e

(Batterham et al., 1996)

lz^77a7

(Batterham et al., 1996)

Fails to complement

lz^g