FlyBase Allele Report: Dmel\M(2)58F[1]

General Information

Symbol

Dmel\M(2)58F¹

Species

D. melanogaster

Name

FlyBase ID

FBal0011923

Feature type

allele

Associated gene

M(2)58F

Associated Insertion(s)

Carried in Construct

Also Known As

M(2)l²

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Polytene chromosomes apparently normal.

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | dominant

(Ferrus, 1975)

abnormal developmental rate | dominant | larval stage

(Dunn and Mossige, 1937)

Minute

(Marygold et al., 2007)

Minute | dominant

(Ferrus, 1975, Dunn and Mossige, 1937)

visible | dominant

(Ferrus, 1975, Dunn and Mossige, 1937, Schultz, 1929)

Phenotype Manifest In

eye

(Dunn and Mossige, 1937)

femur & macrochaeta

(Schultz, 1929)

macrochaeta

(Ferrus, 1975, Dunn and Mossige, 1937)

posterior dorsocentral bristle

(Schultz, 1929)

posterior scutellar bristle

(Schultz, 1929)

Detailed Description

Statement

Reference

Dominantly causes tergite defects in less than 35% of run³ heterozygotes.

(Duffy et al., 1996)

No obvious ovary defect.

(Cramton and Laski, 1994)

Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 19 hours.

(Ferrus, 1975)

Heterozygotes have a Minute bristle phenotype and the eyes occasionally show a slight roughness. Larval development of heterozygotes is delayed by about 0.7 days at 25^oC compared to control siblings. Larval development of heterozygotes is delayed by about 0.9 days at 21 +/- 2^oC compared to control siblings.

(Dunn and Mossige, 1937)

The length of the posterior dorsocentral, posterior scutellar and femur bristles is reduced in heterozygotes compared to wild type.

(Schultz, 1929)

Eyes somewhat rough; veins often show plexus; abdominal sclerites often abnormal; ocelli often reduced. Viability 80-90% wild type and fertility low. 13 hr delay in puparium formation at 25^oC (Brehme, 1939); slight delay in time of second larval molt. Viability, fertility and classification excellent. homozygous lethal in first larval instar. Eggs recognizable have a thin chorion (Li, 1927).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

M(2)58F¹ has phenotype, non-enhanceable by M(3)99E¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-enhanceable by RpS3¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-enhanceable by M(2)28¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-enhanceable by M(3)69E¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-enhanceable by M(3)69E⁵

(Schultz, 1929)

M(2)58F¹ has phenotype, non-enhanceable by M(3)99B¹

(Schultz, 1929)

NOT suppressed by

Statement

Reference

M(2)58F¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

M(2)58F¹ has phenotype, non-suppressible by M(2)28¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-suppressible by M(3)69E¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-suppressible by M(3)69E⁵

(Schultz, 1929)

M(2)58F¹ has phenotype, non-suppressible by M(3)99B¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-suppressible by M(3)99E¹

(Schultz, 1929)

M(2)58F¹ has phenotype, non-suppressible by RpS3¹

(Schultz, 1929)

Enhancer of

Statement

Reference

M(2)58F[+]/M(2)58F¹ is an enhancer of phenotype of J¹

(Schultz, 1929)

NOT Enhancer of

Statement

Reference

M(2)58F¹ is a non-enhancer of phenotype of M(3)99E¹

(Schultz, 1929)

M(2)58F¹ is a non-enhancer of phenotype of RpS3¹

(Schultz, 1929)

M(2)58F¹ is a non-enhancer of phenotype of M(2)28¹

(Schultz, 1929)

M(2)58F¹ is a non-enhancer of phenotype of M(3)69E¹

(Schultz, 1929)

M(2)58F¹ is a non-enhancer of phenotype of M(3)69E⁵

(Schultz, 1929)

M(2)58F¹ is a non-enhancer of phenotype of M(3)99B¹

(Schultz, 1929)

NOT Suppressor of

Statement

Reference

M(2)58F¹ is a non-suppressor of phenotype of M(3)69E¹

(Schultz, 1929)

M(2)58F¹ is a non-suppressor of phenotype of M(3)99E¹

(Schultz, 1929)

M(2)58F¹ is a non-suppressor of phenotype of RpS3¹

(Schultz, 1929)

M(2)58F¹ is a non-suppressor of phenotype of M(3)99B¹

(Schultz, 1929)

M(2)58F¹ is a non-suppressor of phenotype of M(3)69E⁵

(Schultz, 1929)

M(2)58F¹ is a non-suppressor of phenotype of M(2)28¹

(Schultz, 1929)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

342

105860

101814

f^36a ; P{f⁺13}44C P{f⁺13}52 M(2)58F¹ / CyO

101541

M(2)58F¹ / SM1, al² Duox^Cy cn² speck²

102017

f^36a ; P{f⁺13}44C P{f⁺13}52 M(2)58F¹ / CyO ; mwh¹ jv¹

Notes on Origin

Discoverer

Schultz, 7th Jan. 1926.

Comments

M(2)58F¹ complements l(2)SH2053[SH2053] (an insertion in the RpS24 gene), suggesting that M(2)58F¹ does not disrupt RpS24 and may instead disrupt the nearby RpS16 gene.

(Marygold et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

M(2)58F¹

(Marygold et al., 2007)

M(2)l'

M(2)l2

(Duffy et al., 1996)

M(2)l²

(Molnar et al., 2011, Barrio and de Celis, 2004, Cramton and Laski, 1994)

M(2R)l²

(Ferrus, 1975)

M_l'

(Schultz, 1929)

Ml²

(Dunn and Mossige, 1937)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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