FB2026_02 , released June 18, 2026
Allele: Dmel\norpAP45
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General Information
Symbol
Dmel\norpAP45
Species
D. melanogaster
Name
FlyBase ID
FBal0013134
Feature type
allele
Associated gene
Dmel\norpA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Pearn et al., 1996)
Mutagen
ethyl methanesulfonate
(Pearn et al., 1996)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C2896T (nucleotide numbering as in FBrf0047660), producing a premature termination codon.

(Pearn et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The amplitude of quantum bumps in mutant photoreceptors is smaller than wild type (when ATP is present in the intracellular solution during recordings).

      (Hardie et al., 2002)

      The electroretinogram (ERG) of norpA41 flies shows reduced amplitude and slower response kinetics compared to that of wild-type flies.

      (Pearn et al., 1996)

      The amplitude response to vapours of all odorants tested in the maxillary palp is significantly reduced. The antennal response is unaffected. Maxillary palps have no gross anatomical defects and the electrical conduction properties are normal.

      (Riesgo-Escovar et al., 1995)

      intermediate ERG

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      cryb, norpAP45 has abnormal locomotor rhythm phenotype

      (Collins et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When the locomotor activity of wild-type flies are monitored at 18 and 29oC, an earlier evening peak is seen at 18oC. This is not seen in norpA41, cryb mutants.

      (Collins et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Pak.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      norpA41
      norpAP45
      (Delgado et al., 2019, Collins et al., 2004, Hardie et al., 2002, Pearn et al., 1996, Riesgo-Escovar et al., 1995, Pearn et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)