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General Information
Symbol
Dmel\opa1
Species
D. melanogaster
Name
FlyBase ID
FBal0013265
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
opa5H97, opa5H
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Single base change that disrupts the open reading frame and generates a predicted protein lacking the DNA binding domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The maxillary lobe is absent in mutant embryos.

Homozygous embryos have half the number of normal body segments and each is roughly twice the normal width. At embryonic stage 16 none of the three midgut constrictions have formed. At early stages of development interruptions in the visceral mesoderm are observed at many positions along the anterior-posterior axis, as development proceeds interruptions are less frequent. One interruption, coincident with the Antp expression domain, invariably persists.

Pair rule phenotype. Only four complete abdominal segments, although occasionally the remnants of a fifth denticle belt are seen.

Interacts with RpII140wimp maternal effect.

Double mutants with prd4 seem unsegmented.

Odd numbered denticle bands missing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

opa1 is partially rescued by opahs.PB

Comments

Mutant phenotype can be partially rescued by opahs.PB exposed to a 20 minute heat shock at cellularization.

Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Comments
Comments

prd RNA expression has been studied in opa1 hILK double mutant embryos.

The expression of l(1)sc is altered during stage 9 in homozygous mutant embryos.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (20)