FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\brrbp-4
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General Information
Symbol
Dmel\brrbp-4
Species
D. melanogaster
Name
FlyBase ID
FBal0014444
Feature type
allele
Associated gene
Dmel\br
Associated Insertion(s)
Carried in Construct
Also Known As
rbp4, rbpt358
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Crossgrove et al., 1996, O'Keefe et al., 1995, Restifo and Merrill, 1994)
Mutagen
ethyl methanesulfonate
(O'Keefe et al., 1995, Restifo and Merrill, 1994, Belyaeva et al., 1982)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DVM are virtually eliminated (a deficit in thoracic muscle precursors). DLM fibres often remain fused at their ends rather than splitting from three primordia into six DLM fibres. DLM, TTM and the few surviving DVM fibres occupy incorrect attachment sites on the dorsal thorax at epidermal locations normally occupied by other muscle fibres.

      (Sandstrom et al., 1997)

      Heterozygotes with brrbp-1 have the salivary gland tangled in the head capsule and an abnormal proventriculus structure.

      (Restifo and Merrill, 1994)

      Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles. Proventriculus abnormality: foregut-midgut junction less proventriculus-like in appearance.

      (Restifo and White, 1992)

      Intermoult gene transcriptional phenotype.

      (Guay and Guild, 1991)

      Heterozygotes with Df(1)St490 are female sterile, Dp(1;f)101 can restore fertility.

      (Mazina et al., 1991)

      70% penetrance of abnormal SEG-TG separation phenotype, 84% with an abnormal optic lobe position and 51% with brain fusion failure in rbp mutants.

      (Restifo and White, 1991)

      Pupae die at the beginning of eye formation.

      (Belyaeva et al., 1982)

      Adults of the br6/brrbp-4 combination have reduced number of bristles on the palpus and have short, broad wings. Heterozygotes with Df(1)br25 have normal viability and reduced bristle number on the palpus.

      (Belyaeva et al., 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Chromosome carries an additional mutation affecting fertility which lies outside the sta and br loci.

      (Mazina et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (18)