FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rdgA2
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General Information
Symbol
Dmel\rdgA2
Species
D. melanogaster
Name
FlyBase ID
FBal0014458
Feature type
allele
Associated gene
Dmel\rdgA
Associated Insertion(s)
Carried in Construct
Also Known As
rdgAKO14
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Masai et al., 1993)
Mutagen
ethyl methanesulfonate
(Masai et al., 1997, Masai et al., 1993, Suzuki et al., 1990, Inoue et al., 1989)
Progenitor genotype
Cytology
Description

Amino acid replacement: G869D. Nucleotide substitution: G2844A. G869D falls in the highly conserved catalytic domain.

(Masai et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,019,898..9,019,898 [+]
Nucleotide change:

G9019898A

Reported nucleotide change:

G2844A

Amino acid change:

G869D | rdgA-PA; G421D | rdgA-PB; G436D | rdgA-PC; G403D | rdgA-PD; G403D | rdgA-PE; G864D | rdgA-PG; G869D | rdgA-PH; G872D | rdgA-PI; G869D | rdgA-PJ; G869D | rdgA-PK; G869D | rdgA-PL

Reported amino acid change:

G869D

(Masai et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
D17315
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Photoreceptor cells undergo severe degeneration in homozygous flies.

      (Masai et al., 1997)

      Shows abnormal localisation of anti-RDGA protein in adult photoreceptors.

      (Suzuki and Hirosawa, 1994)

      Photoreceptor degeneration occurs during the first week of adult life. Diacylglycerol kinase activity is very low compared to wild-type.

      (Inoue et al., 1989)

      Rhabdomeres are small and irregular in shape one day after eclosion. The degeneration of the mutant rhabdomeres proceeds more rapidly in regions remote from the nuclei.

      (Matsumoto et al., 1988)

      Photoreceptors R7 and R8 are preserved in less than 10% of ommatidia in 7 day old mutant flies. Mosaic analysis indicates that the degeneration defects seen in mutant flies are autonomous to the retina. The electroretinogram (ERG) of 7 day old flies shows reduced receptor potentials.

      (Harris and Stark, 1977)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      rdgA2 has phenotype, suppressible by su(rdgA)4040

      (Georgiev et al., 2012)
      NOT suppressed by
      Statement
      Reference

      rdgA2 has photoreceptor neuron phenotype, non-suppressible by inaC5

      (Masai et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The photoreceptor degeneration phenotype is not alleviated by the inaC5 mutation in double mutant flies.

      (Masai et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Alleles can be ranked with respect to how much R7 and R8 are affected in each mutant; rdgA1 = rdgA2 > rdgA4 > rdgA3.

      (Harris and Stark, 1977)

      rdgA2 flies lack diacylglycerol kinase activity in a gene dosage-dependent manner, suggesting that rdgA codes for diacylglycerol kinase.

      (Inoue et al., 1989)

      Incorporation of 3H-amino acids into the rhabdomeres is much lower than wild-type.

      (Suzuki et al., 1990)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (2)
      References (13)