FlyBase Allele Report: Dmel\rst[irreC1]

General Information

Symbol

Dmel\rst^irreC1

Species

D. melanogaster

Name

FlyBase ID

FBal0014800

Feature type

allele

Associated gene

Dmel\rst

Associated Insertion(s)

P{}rst^irreC1

Carried in Construct

Also Known As

irreC^UB883, irreC-rst^UB883

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

PM hybrid dysgenesis

(Ramos et al., 1993, Boschert et al., 1990, Ramos et al., 1989)

P-element activity

ethyl methanesulfonate

(Fischbach, 2001.12.10)

Progenitor genotype

Associated Insertion(s)

P{}rst^irreC1

Cytology

Description

P-element insertion in the 5' flanking sequences.

(Ramos et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

optic chiasma | adult stage

(Ramos et al., 1989)

presumptive embryonic/larval muscle system

(Strunkelnberg et al., 2001)

Detailed Description

Statement

Reference

Homozygous embryos show some muscle defects. Individual muscles are missing in some, but not all segments.

(Strunkelnberg et al., 2001)

Flies have a weak to non-detectable rough eye phenotype.

(Tanenbaum et al., 2000)

Aberrant axonal projections.

(Ramos et al., 1993)

Severe disorder of second optic chiasm.

(Boschert et al., 1990)

Specific pathfinding defects in both the inner and outer optical chiasms.

(Ramos et al., 1989)

Eye mutant. Inner optic chiasma in disorder. Bundles of fibers connecting medulla and lobula plate penetrate neuropil of lobula. shows 94% penetrance for optic-lobe defects; good viability and fertility; expressivity highly variable (e.g., anatomical abnormalities can appear in only first but not second chiasm, or vice versa, or in only left or right side of the head).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

rst^irreC1 has phenotype, enhanceable by Delta^K75

(Gorski et al., 2000)

rst^irreC1 has phenotype, enhanceable by Delta^HD82

(Gorski et al., 2000)

rst^irreC1 has phenotype, enhanceable by Delta^E58

(Gorski et al., 2000)

rst^irreC1 has phenotype, enhanceable by Delta^J111

(Gorski et al., 2000)

rst^irreC1 has phenotype, enhanceable by Delta^J17

(Gorski et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by Delta^E58

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by Delta^E58

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by Delta^K75

(Tanenbaum et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by E(rst)H125^H125

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by E(rst)H125^H125

(Tanenbaum et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by E(rst)H253^H253

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by E(rst)H253^H253

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by E(rst)D184^D184

(Tanenbaum et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by E(rst)D184^D184

(Tanenbaum et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by Delta^J111

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by Delta^J111

(Tanenbaum et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by Delta^J17

(Tanenbaum et al., 2000)

rst^irreC1 has ommatidium phenotype, enhanceable by Delta^J17

(Tanenbaum et al., 2000)

rst^irreC1 has eye phenotype, enhanceable by Delta^K75

(Tanenbaum et al., 2000)

NOT Enhancer of

Statement

Reference

rst^irreC1 is a non-enhancer of muscle founder cell | embryonic stage phenotype of sns^s660

(Shelton et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

sns^s660 rst^irreC1 embryos show a similar number of eve-positive DA1 founder cell nuclei as sns^s660 embryos at stage 15-16.

(Shelton et al., 2009)

The severity of the rst^irreC1 rough eye phenotype is increased by E(rst)D184^D184, Dl^E58, E(rst)H125^H125, E(rst)H253^H253, Dl^J17, Dl^J111 or Dl^K75.

(Tanenbaum et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

J. Campos-Ortega.

Arose in: Berlin wild-type (M-cytotype) females x Harwich (P-cytotype) males.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

UB883

(Fischbach, 2001.12.10, Boschert et al., 1990)

UB883¹

irreC-rst^UB883

(Gorski et al., 2000, Tanenbaum et al., 2000)

irreC1

(Fischbach, 2001.12.10)

irreC¹

irreC^UB883

(Dworak et al., 2001, Araujo et al., 1996, Schneider et al., 1995, Ramos et al., 1993, Ramos et al., 1993, Ramos et al., 1991, Ramos et al., 1991, Boschert et al., 1990)

rst^irreC1

(Shelton et al., 2009)

rst^irreCUB883

(Simon et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBal0017337

References (17)

Report Sections

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