FB2026_02 , released June 18, 2026
Allele: Dmel\slgA1
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General Information
Symbol
Dmel\slgA1
Species
D. melanogaster
Name
FlyBase ID
FBal0015697
Feature type
allele
Associated gene
Dmel\slgA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Hayward et al., 1993)
Mutagen
ethyl methanesulfonate
(Miklos et al., 1987)
Progenitor genotype
Cytology
Description

No polymorphism detectable with Southern blot.

(Hayward et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mosaic analysis indicates that the focus of the slgA mutation maps to the thoracic ganglion. Proline oxidase levels are dramatically reduced, and free proline elevated in mutants.

      (Hayward et al., 1993)

      Homozygous viable. Homozygous germline clones display no maternal effect. Flies derived from heterozygous mothers do not move towards a light source.

      (Perrimon et al., 1989)

      slgA1/Df(1)Q539 flies have reduced viability and show defective phototaxis. slgA1/Df(1)GA104 flies have reduced viability, defective phototaxis, severe motor debilitation and are often mired in the food medium. They also have a weak or non-existent optomotor response. slgA1/Df(1)GE263 flies have reduced viability, defective phototaxis, show uncoordinated behaviour and have a weak or non-existent optomotor response. slgA1/Df(1)17-257 flies have reduced viability, defective phototaxis and a weak or non-existent optomotor response.

      (Miklos et al., 1987)

      slgA1 flies do not have small optic lobes.

      (Yamamoto et al., 1987)

      Isolated as defective in fast phototaxis, using counter-current-distribution (CCD) machine; also turned out to have poor (negative) geotaxis in this machine; yet mutant males showed some positive optomotor responses and had a normal electroretinogram; hence termed sluggish (as opposed to phototaxis-defective per se); Markow and Merriam (1977) confirmed aberrant CCD phototactic response; in maze tests the mutant was found to be quite photonegative (more so than wild type) and seemingly normal in geotaxis (Markow and Merriam, 1977). slgA causes poor viability, as well as aberrant behavior in hemizygous females (Miklos et al., 1987); in mosaics studied for sluggishness, a mutant leg seemed to be debilitated independently of behavior of other legs, with the six foci for such movement deficits mapping to the ventral blastoderm (A. Ghysen, cited in Hall, 1978).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      slgA1 has abnormal phototaxis phenotype, non-suppressible by Septin1GL1

      (Hayward et al., 1993)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mutant phototactic behaviour and inactivity phenotypes of slgA1 are not rescued by Sep1GL1. Proline oxidase levels are dramatically reduced, and free proline elevated in mutants, and these effects are also not rescued by Sep1GL1.

      (Hayward et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      slgA1 is rescued by slgA+t14.7

      (Hayward et al., 1993)
      Comments

      Mutant phototactic behaviour and inactivity phenotypes of slgA1 rescued by slgA+t14.7. Proline oxidase levels are dramatically reduced, and free proline elevated in mutants, and these effects are also rescued by slgA+t14.7.

      (Hayward et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Eichenberger and Benzer.

      Comments
      Comments

      slgA1 is not an allele of sol; slgA1 complements the mutations sol9, sol3, sol4, sol6 and sol1 with regard to photo- and geotaxis.

      (Yamamoto et al., 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      slgEE85
      (Perrimon et al., 1989)
      slgA1
      slgAEE85
      (Miklos et al., 1987, Miklos et al., 1987, Yamamoto et al., 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)