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General Information
Symbol
Dmel\snk1
Species
D. melanogaster
Name
FlyBase ID
FBal0015909
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
snk073, mel(3)4
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C13041293T

Reported nucleotide change:

C325T

Amino acid change:

Q109term | snk-PA; Q109term | snk-PB; Q109term | snk-PC

Reported amino acid change:

Q109term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Point mutation in the catalytic site.

Amino acid replacement: Q109term.

Nucleotide substitution: C325T.

Mutation is within the middle of the proenzyme region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos produced by snk1/snk2 mothers are completely dorsallzed, lacking both ventral denticles and Filzkorper.

The mean ln (natural logarithm) circulating hemocyte concentration (CHC) value of snk2/snk1 larvae is statistically indistinguishable from that of control siblings. The ability of snk2/snk1 larvae to encapsulate L.boulardi eggs is not significantly different from the encapsulation activity of control larvae.

Embryos from snk1/snk2 mothers lack all ventral structures.

Bacterially challenged mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

Injection of tor::tubt4021t construct and the pll::tort4021p construct into snk1/snk2 embryos induces dorsoventral pattern elements.

Strongly dorsalized.

Embryos produced by homozygous mothers show extreme dorsalized phenotype; only dorsally derived cuticle remains, resulting in a hollow tube of dorsal ectoderm. No paternal rescue, even by two doses of snk+; dorsalizes the expression of ftz such that entire ftz stripes in the blastoderm exhibit the wide dorsal conformation and do not narrow ventrally as is normal.

Perivitelline fluid from Tl and dl donors was capable of restoring polarized gastrulation movements and cuticular elements.

Dorsalized embryos: all cuticle cells along the dorsoventral axis behave like dorsal cells of the wild type embryo. zen expression pattern refines at stage 5, dpp pattern does not refine at all, twi and sna are expressed during late stages of embryogenesis.

Embryos derived from homozygous females are dorsalised.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

snk1 has phenotype, non-enhanceable by gdWT.cHa

NOT suppressed by
Statement
Reference

snk1 has phenotype, non-suppressible by gdWT.cHa

NOT Enhancer of
Statement
Reference

snk1 is a non-enhancer of phenotype of gdWT.cHa

NOT Suppressor of
Statement
Reference

snk1 is a non-suppressor of phenotype of gdWT.cHa

Additional Comments
Genetic Interactions
Statement
Reference

Embryos derived from Spn27Aex32/Df(2L)BSC7 ; snk1/snk2 females are completely dorsalised.

The zygotic semi-lethality of cact7 homozygotes is not suppressed by snk1.

Double mutant combinations with eaD1 and eaD3 are strongly dorsalized.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (36)