FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\speck2
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General Information
Symbol
Dmel\speck2
Species
D. melanogaster
Name
FlyBase ID
FBal0015981
Feature type
allele
Associated gene
Dmel\speck
Associated Insertion(s)
412{}881
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    412{}881
    Cytology
    Description

    7566bp 412 element is inserted in the 5'UTR in exon 1 of isoform RB of speck. The size, structure and location of the 412 insertion in speck2 is identical to that found in speck1 (the insertion in both mutants is represented by 412{}881 in the annotated reference genome). Although the speck2 mutant has a stronger phenotype than speck1, no additional change has been identified in two speck2 chromosomes compared to speck1.

    (Spana et al., 2020)

    412 insertion in 5' UTR of AANAT1 (aka 'Dat').

    (Miller et al., 2018)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        speck2/Df(2R)BSC356 adults exhibit ectopic pigmentation in the wing hinge and a slightly darker body color.

        speck2/speckMB02738 adults exhibit ectopic pigmentation in the wing hinge.

        speck2 pupal cases exhibit excess pigmentation at the anal pad.

        (Spana et al., 2020)

        Body colour: dark; darker than sp1.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        speck2/speckMB02738 has visible | adult stage phenotype, suppressible by Bmor\AANATUAS.cOa/Scer\GAL4Tub.PU

        (Spana et al., 2020)
        NOT Enhancer of
        NOT Suppressor of
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        speck2/speckMB02738 has wing hinge phenotype, suppressible by Bmor\AANATUAS.cOa/Scer\GAL4Tub.PU

        (Spana et al., 2020)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (102)
        Notes on Origin
        Discoverer

        Bridges, June 1925.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        sp2
        (Miller et al., 2018)
        speck2
        (Spana et al., 2020)
        Name Synonyms
        Secondary FlyBase IDs
          References (9)