FlyBase Allele Report: Dmel\sv[de]

General Information

Symbol

Dmel\sv^de

Species

D. melanogaster

Name

depilate

FlyBase ID

FBal0016606

Feature type

allele

Associated gene

Dmel\sv

Associated Insertion(s)

Tirant{}sv^de

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Kavaler et al., 1999)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

Tirant{}sv^de

Cytology

Description

Insertion of a 5.1kb defective Tirant element (deleted from position 4316 to 7456 and contains only the last three of six 102bp repeats) within a 0.25kb EcoRI fragment approximately 1.6kb upstream of the transcription start site.

(Fu et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Kavaler et al., 1999)

sterile

(Goldschmidt, 1944)

uncoordinated

(Kavaler et al., 1999)

visible | recessive

(Kavaler et al., 1999, Fu et al., 1998)

Phenotype Manifest In

anterior dorsocentral bristle & trichogen cell

(Kavaler et al., 1999)

interommatidial bristle

(Fu et al., 1998)

macrochaeta

(Kavaler et al., 1999, Fu et al., 1998)

microchaeta

(Fu et al., 1998)

posterior dorsocentral bristle & tormogen cell

(Kavaler et al., 1999)

scutum & macrochaeta

(Kavaler et al., 1999)

scutum & macrochaeta & tormogen cell

(Kavaler et al., 1999)

scutum & macrochaeta & trichogen cell

(Kavaler et al., 1999)

scutum & microchaeta

(Kavaler et al., 1999)

Detailed Description

Statement

Reference

sv^de/Df(4)G flies have more severe bristle defects than sv^de homozygotes. Almost all homozygotes eclose, but the adults are uncoordinated and die within a few days of eclosion. Homozygotes show bristle defects over the entire body surface. The microchaetae and macrochaetae of the notum can have stunted or misshapen shafts, or may have empty sockets. Macrochaetae also occasionally show a double socket phenotype. The empty socket phenotype is often seen at the position of the anterior dorsocentral bristle, while the posterior dorsocentral bristle more often has a double socket phenotype.

(Kavaler et al., 1999)

sv^spa-20 strongly enhances the bristle phenotype of sv^de in transheterozygotes; in the eyes there is nearly complete loss of bristle shafts, and in other parts of the body, loss or reduction of the shafts of microchaetae and macrochaetae is more severe than in sv^de homozygotes.

(Fu et al., 1998)

More extreme than svⁿ. Thorax denuded over large areas. Phenotype more severe than H²; bristleless sockets found on adult integumentary derivatives of all imaginal discs; nearly 100% penetrance on thorax. Shafts, where present, often bent, twisted, or forked; up to 97% of bristle organs on wing costa and distal leg segments fail to produce normal shafts. Bracts present when bristle normally formed; otherwise bracts missing (Tobler, Rothenbuhler and Nothiger, 1973). Both sexes sterile. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

H^hs.PB, sv^de has visible | heat sensitive phenotype

(Kavaler et al., 1999)

H^hs.PB, sv^de has visible | recessive phenotype

(Kavaler et al., 1999)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

sv^de has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Other

Statement

Reference

H^hs.PB, sv^de has microchaeta & trichogen cell phenotype

(Kavaler et al., 1999)

H^hs.PB, sv^de has microchaeta & tormogen cell phenotype

(Kavaler et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Adults in which H^hs.PB has been expressed during differentiation of the microchaetae show a double shaft phenotype in the microchaetae. This phenotype is suppressed if the flies are also homozygous for sv^de; large territories devoid of external bristle structures are seen.

(Kavaler et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

662

sv^de/Dp(2;4)ey^D, Ablp^eyD: ey^D

Notes on Origin

Discoverer

E.M. Wallace, 24th Jan. 1937.

R.B. Goldschmidt.

(Goldschmidt, 1944)

Comments

The order of severity of the microchaete phenotype is: sv⁶ = sv⁷ = sv⁸ > sv^de > svⁿ.

(Kavaler et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sv^de

Name Synonyms

depilate

(Goldschmidt, 1944)

Secondary FlyBase IDs

References (4)

Report Sections

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