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General Information
Symbol
Dmel\Diap11
Species
D. melanogaster
Name
FlyBase ID
FBal0016769
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
th1
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

As in wild type, th1 mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

As in wild type, th1/th4 mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

The arista of th1 flies lacks all lateral branches.

Homozygous mutant or th1/Df(3L)th102 animals have abnormal aristae, they show an almost complete lack of branching, though the strength of this phenotype is variable. Often, a few short extensions (usually shorter than the dorsal laterals) can be seen projecting from various locations along the central core, though not in any clear pattern. In the antennal imaginal discs of third instar larvae, there is a considerable increase in the number of apoptotic cells near the aristal progenitor cell cluster compared to wild-type. But at other stages, cell death appears normal.

Arista lack the normally occurring side branches.

Geotaxis score significantly lower than for Canton S in a Hirsch-type geotaxis maze.

Aristae threadlike, without side branches. Mutation affects development of tarsal claws at 29oC (Mglinetz and Ivanov, 1975). Deficiency for th homozygous lethal (Ward and Alexander, 1957; Korge, 1972). Mutant males and females less successful in mating than wild-type (Burnet, Connolly and Dennis, 1971).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Diap11 has arista phenotype, suppressible by DriceΔ1

Diap11 has arista phenotype, suppressible | partially by DarkCD4

Enhancer of
Statement
Reference

Diap11/th[+] is an enhancer of eye phenotype of LrrkI1915T.UAS, Scer\GAL4GMR.PF, foxoUAS.cKb

Diap11 is an enhancer of phenotype of al1

Additional Comments
Genetic Interactions
Statement
Reference

The eye phenotype caused by co-expression of foxoScer\UAS.cKb and LrrkI1915T.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by th1/+.

IceΔ1 suppresses the loss of lateral shafts on the arista of th1 flies.

th1, ArkCD4 animals exhibit considerable suppression of the th1 mutant aristae phenotype, but they remain abnormal sowing no consistent pattern either in the length of laterals or in distribution. Furthermore laterals are often forked.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (222)
Notes on Origin
Discoverer

Bridges, 31st Oct. 1922.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (18)